Role of aflatoxin B1 as a risk for primary liver cancer in north Indian population.

Abstract

OBJECTIVES:

The present study was designed to determine whether aflatoxin B1 (AFB1) exposure has any role to play in hepatocellular carcinoma (HCC) patients from northern India.

DESIGN AND METHODS:

A total of 266 HCC patients and 251 patients of chronic liver disease without-HCC were enrolled into the study. All samples were screened for serological markers for hepatitis B and C infections and levels of AFB1 in food and urine samples.

RESULTS:

A threefold (OR=3.43) and five-fold (OR=5.47) increased risk of HCC was observed amongst HBV infection and AFB1-levels in food and urine samples, respectively. However, a non-significant risk was observed with respect to HCV infection (OR=1.27) and alcohol consumption (OR=1.18). A threefold (OR=3.15) increased risk of HCC was observed amongst cases of non-viral etiology with respect to urinary AFB1.

CONCLUSION:

The data provides an exposure and disease risk information for establishing intervention studies to diminish the impact of aflatoxin exposure in Indian population.

• Authors: Mohammad Asim, Manash P Sarma, L Thayumanavan, P Kar
• Journal: Clinical biochemistry (Clin Biochem) Vol. 44 Issue 14-15 Pg. 1235-40 (Oct 2011) ISSN: 1873-2933 [Electronic] United States
• PMID: 21854762 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011. Published by Elsevier Inc.

Chemical References

• aflatoxin-B1-N7-guanine
• Guanine
• Aflatoxin B1

Topics

• Adult
• Aflatoxin B1 (analogs & derivatives, analysis, urine)
• Alcohol Drinking
• Carcinoma, Hepatocellular (epidemiology, etiology)
• Case-Control Studies
• Chronic Disease
• Female
• Food Analysis
• Food Microbiology
• Guanine (analogs & derivatives)
• Hepatitis B (complications)
• Hepatitis C (complications)
• Humans
• India
• Liver Diseases (epidemiology)
• Liver Neoplasms (epidemiology, etiology)
• Male
• Middle Aged
• Risk Factors