Abstract |
Viruses commonly use host cell survival mechanisms to their own advantage. We show that Akt, an important signaling kinase involved in cell survival, phosphorylates the RNA-dependent RNA polymerase (RdRp) from norovirus, the major cause of gastroenteritis outbreaks worldwide. The Akt phosphorylation of RdRp appears to be a feature unique to the more prevalent norovirus genotypes such as GII.4 and GII.b. This phosphorylation event occurs at a residue (Thr33) located at the interface where the RdRp finger and thumb domains interact and decreases de novo activity of the polymerase. This finding provides fresh insights into virus-host cell interactions.
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Authors | John-Sebastian Eden, Laura J Sharpe, Peter A White, Andrew J Brown |
Journal | Journal of virology
(J Virol)
Vol. 85
Issue 20
Pg. 10894-8
(Oct 2011)
ISSN: 1098-5514 [Electronic] United States |
PMID | 21849454
(Publication Type: Journal Article)
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Chemical References |
- Threonine
- Oncogene Protein v-akt
- RNA-Dependent RNA Polymerase
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Topics |
- Host-Pathogen Interactions
- Humans
- Kinetics
- Models, Molecular
- Norovirus
(physiology)
- Oncogene Protein v-akt
(metabolism)
- Phosphorylation
- RNA-Dependent RNA Polymerase
(metabolism)
- Threonine
(metabolism)
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