Abstract | BACKGROUND: AIM: METHODS: RESULTS: The levels of PDMP, sCD40L, sP- selectin, sE- selectin, and sL- selectin were higher in diabetic patients than in hypertensive patients, while there were no significant differences between hypertensive and hyperlipidemic patients. Before miglitol treatment, the adiponectin level of diabetic patients was lower than that of hypertensive patients. Miglitol therapy significantly decreased the plasma PDMP and sCD40L levels relative to baseline. Miglitol also caused a significant decrease of sP- selectin, sE- selectin, and sL- selectin. On the other hand, miglitol therapy led to a significant increase in adiponectin after 4 months of administration compared with baseline. Furthermore, the reduction of platelet activation markers and selectins during miglitol therapy was significantly greater in the responder ( adiponectin-improved) group than the nonresponder group of diabetic patients. CONCLUSION:
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Authors | Shosaku Nomura, Seitaro Omoto, Takashi Yokoi, Shinya Fujita, Ryotaro Ozasa, Noritaka Eguchi, Akira Shouzu |
Journal | International journal of general medicine
(Int J Gen Med)
Vol. 4
Pg. 539-45
( 2011)
ISSN: 1178-7074 [Electronic] New Zealand |
PMID | 21845063
(Publication Type: Journal Article)
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