Anticonvulsants as adjuncts for the neuroleptic treatment of schizophrenic psychoses: a clinical study with beclamide.

A recent study showed an adjuvant effect of carbamazepine in the neuroleptic treatment of acute schizophrenic psychoses. Since beclamide (beta-chlorpropionamide) was reported to reduce the neuroleptic doses required, the combination haloperidol-beclamide was tested using a double-blind, placebo-controlled study in 23 inpatients with an acute schizophrenic psychosis. In both groups patients received haloperidol and either beclamide or placebo. Every 7 d the treating psychiatrist could increase the haloperidol dose by 3 mg per day if clinically necessary. Chlorprothixene and biperiden were on hand as additional medication. After 28 d beclamide or placebo were discontinued under a constant dose of haloperidol and a final rating with the Inpatient Multidimensional Rating Scale, Brief Psychiatric Rating Scale, and Extrapyramidal Symptom Scale was carried out. Without reaching statistical significance, the beclamide group needed a lower dose of neuroleptic medication, showed fewer side effects and a more pronounced psychopathological improvement.
AuthorsC Raptis, D Garcia-Borreguero, M M Weber, M Dose, D Bremer, H M Emrich
JournalActa psychiatrica Scandinavica (Acta Psychiatr Scand) Vol. 81 Issue 2 Pg. 162-7 (Feb 1990) ISSN: 0001-690X [Print] DENMARK
PMID2183543 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anticonvulsants
  • Propionates
  • Chlorprothixene
  • beclamide
  • Haloperidol
  • Anticonvulsants (administration & dosage)
  • Chlorprothixene (administration & dosage)
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Haloperidol (administration & dosage)
  • Humans
  • Male
  • Propionates (administration & dosage)
  • Psychiatric Status Rating Scales
  • Psychotic Disorders (drug therapy)
  • Randomized Controlled Trials as Topic
  • Schizophrenia (drug therapy)
  • Schizophrenic Psychology

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