Abstract | BACKGROUND/AIMS: Myelosuppression is a serious adverse effect of chemotherapy, but its risk factors remain largely unknown. The present study retrospectively evaluated clinical data obtained before therapy to clarify the risk factors for myelosuppression after chemoradiotherapy in patients with esophageal cancer. METHODOLOGY: One-hundred-and-eight patients who received 5-fluorouracil combined with platinum and 60Gy radiation for esophageal cancer were analyzed. The endpoint of this survey was the occurrence of grade 3 or higher myelosuppression ( neutropenia, anemia or thrombocytopenia). Risk factors significantly related to myelosuppression were extracted using logistic regression analysis. RESULTS: CONCLUSIONS: It was found that performance status, bone marrow function and hoarseness are the most important factors for chemoradiotherapy-induced myelosuppression in esophageal cancer. The prediction of myelosuppression is expected to be useful for the determination of the appropriate therapeutic approach for each patient by a physician.
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Authors | Mari Kogo, Manami Watahiki, Tomiko Sunaga, Kazuhiro Kaneko, Keiichiro Yoneyama, Michio Imawari, Yuji Kiuchi |
Journal | Hepato-gastroenterology
(Hepatogastroenterology)
2011 May-Jun
Vol. 58
Issue 107-108
Pg. 802-8
ISSN: 0172-6390 [Print] Greece |
PMID | 21830394
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Anemia
(etiology)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Bone Marrow
(drug effects, radiation effects)
- Combined Modality Therapy
- Esophageal Neoplasms
(therapy)
- Female
- Fluorouracil
(adverse effects)
- Humans
- Male
- Middle Aged
- Neutropenia
(etiology)
- Platinum
(adverse effects)
- Risk Factors
- Thrombocytopenia
(etiology)
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