[Efficacy and safety of aprepitant in patients with breast cancer].

Abstract

We retrospectively analyzed the efficacy and safety of aprepitant in breast cancer patients who were treated with FEC(5- fluorouracil, epirubicin, cyclophosphamide)or EC(epirubicin, cyclophosphamide). We divided patients into two groups according to the aprepitant approval period. The rate of severe nausea(@Grade 2)was significantly less in patients with aprepitant(acute 10. 0%, delayed 15. 0%)than those without aprepitant(acute 29. 1%, delayed 30. 9%). Complete response( no vomiting and no use of rescue therapy)in the acute phase was significantly higher in the aprepitant pretreated group than in the no aprepitant group(82. 5% vs 61. 8%, respectively). Moreover, complete response in the delayed phase was also higher in the aprepitant group than in the no aprepitant group(82. 5%vs 58. 2%, respectively). Pre-treatment with aprepitant did not increase adverse events including constipation and elevation of alanine transaminase. The aprepitant was effective in terms of prevention of chemotherapy-induced nausea and vomiting in patients treated with an anthracycline- based regimen.

• Authors: Hisashi Tagashira, Tetsuaki Matsuhisa, Isao Oze, Sachiko Kiyoto, Mina Takahashi, Fumikata Hara, Daisuke Takabatake, Seiki Takashima, Kenjiro Aogi, Shozo Osumi, Hisae Eguchi
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 38 Issue 8 Pg. 1307-11 (Aug 2011) ISSN: 0385-0684 [Print] Japan
• PMID: 21829069 (Publication Type: Journal Article)

Chemical References

• Morpholines
• Aprepitant
• Epirubicin
• Cyclophosphamide
• Fluorouracil

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Aprepitant
• Breast Neoplasms (drug therapy)
• Cyclophosphamide (adverse effects, therapeutic use)
• Epirubicin (adverse effects, therapeutic use)
• Female
• Fluorouracil (adverse effects, therapeutic use)
• Humans
• Middle Aged
• Morpholines (adverse effects, therapeutic use)
• Nausea (prevention & control)
• Retrospective Studies