Abstract |
The detection of antibodies against aquaporin-4 (AQP4) has improved the diagnosis of neuromyelitis optica (NMO). We evaluated a recently established cell-based anti-AQP4 assay in 273 patients with inflammatory CNS demyelination. The assay had a specificity of 99% and a sensitivity of 56% to detect all NMO patients and of 74% to detect the recurrent NMO patients, similar to the initial studies reported. AQP4 antibodies were absent in monophasic NMO patients, while samples in recurrent cases remained positive during follow-up. We conclude that the pathogenesis of monophasic NMO may be different from that of relapsing NMO.
|
Authors | Immy A Ketelslegers, Piet W Modderman, Anke Vennegoor, Joep Killestein, Dörte Hamann, Rogier Q Hintzen |
Journal | Multiple sclerosis (Houndmills, Basingstoke, England)
(Mult Scler)
Vol. 17
Issue 12
Pg. 1527-30
(Dec 2011)
ISSN: 1477-0970 [Electronic] England |
PMID | 21828202
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- AQP4 protein, human
- Aquaporin 4
- Autoantibodies
- Immunoglobulin G
|
Topics |
- Aquaporin 4
(immunology)
- Autoantibodies
(blood)
- Diagnosis, Differential
- Fluorescent Antibody Technique, Indirect
- Follow-Up Studies
- Humans
- Immunoglobulin G
(blood)
- Multiple Sclerosis
(diagnosis, immunology)
- Neuromyelitis Optica
(diagnosis, immunology)
- Recurrence
- Sensitivity and Specificity
|