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Antibodies against aquaporin-4 in neuromyelitis optica: distinction between recurrent and monophasic patients.

Abstract
The detection of antibodies against aquaporin-4 (AQP4) has improved the diagnosis of neuromyelitis optica (NMO). We evaluated a recently established cell-based anti-AQP4 assay in 273 patients with inflammatory CNS demyelination. The assay had a specificity of 99% and a sensitivity of 56% to detect all NMO patients and of 74% to detect the recurrent NMO patients, similar to the initial studies reported. AQP4 antibodies were absent in monophasic NMO patients, while samples in recurrent cases remained positive during follow-up. We conclude that the pathogenesis of monophasic NMO may be different from that of relapsing NMO.
AuthorsImmy A Ketelslegers, Piet W Modderman, Anke Vennegoor, Joep Killestein, Dörte Hamann, Rogier Q Hintzen
JournalMultiple sclerosis (Houndmills, Basingstoke, England) (Mult Scler) Vol. 17 Issue 12 Pg. 1527-30 (Dec 2011) ISSN: 1477-0970 [Electronic] England
PMID21828202 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • AQP4 protein, human
  • Aquaporin 4
  • Autoantibodies
  • Immunoglobulin G
Topics
  • Aquaporin 4 (immunology)
  • Autoantibodies (blood)
  • Diagnosis, Differential
  • Fluorescent Antibody Technique, Indirect
  • Follow-Up Studies
  • Humans
  • Immunoglobulin G (blood)
  • Multiple Sclerosis (diagnosis, immunology)
  • Neuromyelitis Optica (diagnosis, immunology)
  • Recurrence
  • Sensitivity and Specificity

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