Abstract | PURPOSE: PATIENTS AND METHODS: RESULTS: We included 235 patients with anal cancer. The 5-year cumulative incidences of tumor-related and therapy-related colostomy were 26% (95% CI, 21% to 32%) and 8% (95% CI, 5% to 12%), respectively. Tumor size greater than 6 cm versus less than 4 cm was a risk factor for tumor-related colostomy (adjusted HR, 3.8; 95% CI, 1.7 to 8.1), and local excision before radiotherapy was a risk factor for therapy-related colostomy (adjusted HR, 4.5; 95% CI, 1.5 to 13.5). CONCLUSION:
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Authors | Kåre G Sunesen, Mette Nørgaard, Lilli Lundby, Hanne Havsteen, Steen Buntzen, Ole Thorlacius-Ussing, Søren Laurberg |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 29
Issue 26
Pg. 3535-40
(Sep 10 2011)
ISSN: 1527-7755 [Electronic] United States |
PMID | 21825256
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Agents
(adverse effects)
- Anus Neoplasms
(pathology, radiotherapy, surgery)
- Cohort Studies
- Colostomy
(statistics & numerical data)
- Combined Modality Therapy
(adverse effects)
- Denmark
(epidemiology)
- Female
- Humans
- Male
- Middle Aged
- Proportional Hazards Models
- Radiotherapy
(adverse effects)
- Risk Factors
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