Effects of variant rs346473 in ARHGAP24 gene on disease progression of HBV infection in Han Chinese population.

Abstract

Host genetic, environmental and viral factors are classified as three categories that determine clinical outcomes of hepatitis B virus (HBV) infection. The objective of this study was to detect the associations between polymorphisms rs346473 and rs346482 in Rho GTPase-activating protein 24 (ARHGAP24) gene and disease progression of HBV infection in Han Chinese population. These two SNPs were found by our DNA pooling using Affymetrix Genome-Wide Human Mapping SNP6.0 Array in HBV carriers, and verified by using TaqMan 7900HT Sequence Detection System with 758 progressed HBV carriers versus 300 asymptomatic HBV carriers (AsC) in a discovery phase and 971 progressed HBV carriers versus 328 AsC in a replication phase. Multivariable logistic regression revealed that individuals with genotype TT at variant rs346473 displayed remarkable correlations with disease progression of HBV infection both in the discovery phase (OR, 2.693; 95% CI, 1.928-3.760; P=6.2×10(-9); additive model) and the replication phase (OR, 1.490; 95% CI, 1.104-2.012; P=9.0×10(-3); additive model). These two SNPs were in strong linkage disequilibrium with D'=0.99 and r (2)=0.951, and haplotype TT disclosed an increased susceptibility to HBV progression (OR, 1.980; 95% CI, 1.538-2.545; P=8.1×10(-8)). These findings suggest that polymorphism rs346473 in the ARHGAP24 gene might be a part of the genetic variants underlying the susceptibility of HBV carriers to disease progression.

• Authors: Lifeng Liu, Jinjian Yao, Jin Li, Jinliang Zhang, Jinling Yu, Xiaorui Jiang, Shuzhen Sun, Qing Liu, Ying Chang, Yongwen He, Jusheng Lin
• Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban (J Huazhong Univ Sci Technolog Med Sci) Vol. 31 Issue 4 Pg. 482 (Aug 2011) ISSN: 1672-0733 [Print] China
• PMID: 21823009 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• ARHGAP24 protein, human
• GTPase-Activating Proteins

Topics

• Adult
• Asian People (genetics)
• Disease Progression
• Female
• GTPase-Activating Proteins (genetics)
• Genotype
• Hepatitis B (genetics, pathology, virology)
• Humans
• Male
• Polymorphism, Single Nucleotide (genetics)