Abstract |
N-terminal propeptide of type I procollagen (PINP) is a marker of newly formed type I collagen. However, its role in hypophosphatemic rickets/ osteomalacia has not yet been established. Metabolic bone markers were examined in patients with oncogenic osteomalacia (OOM) and X-linked hypophosphatemic rickets (XLH), and in healthy controls. OOM and XLH patients were found to have hypophosphatemia secondary to elevated levels of serum fibroblast growth factor 23 (FGF-23). OOM patients had reduced levels of 1,25-dihydroxy vitamin D (1,25D) compared with XLH patients and healthy controls, despite attenuation of the reduction in these levels in the XLH patients secondary to active vitamin D supplementation. In contrast to patients with XLH, OOM patients showed a significant increase in serum PINP, which is suggestive of accelerated bone matrix formation. Bone alkaline phosphatase (BAP) and the BAP/PINP ratio were also increased in OOM but not in XLH patients, suggesting the presence of a disturbance in bone mineralization in OOM. Long-term supplementation of active form vitamin D and inorganic phosphate (IP) may have attenuated the defect in bone mineralization in the XLH patients, resulting in the normalization of PINP, BAP, and the BAP/PINP ratio. The present results suggest that, as with BAP, PINP is an appropriate metabolic bone marker in the assessment of hypophosphatemic rickets/ osteomalacia.
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Authors | Yuki Nagata, Yasuo Imanishi, Akira Ishii, Masafumi Kurajoh, Koka Motoyama, Tomoaki Morioka, Hiroshi Naka, Katsuhito Mori, Takami Miki, Masanori Emoto, Masaaki Inaba |
Journal | Endocrine
(Endocrine)
Vol. 40
Issue 2
Pg. 315-7
(Oct 2011)
ISSN: 1559-0100 [Electronic] United States |
PMID | 21822687
(Publication Type: Letter, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Biomarkers, Tumor
- Ergocalciferols
- FGF23 protein, human
- Peptide Fragments
- Procollagen
- procollagen Type I N-terminal peptide
- 1,25-dihydroxyergocalciferol
- Fibroblast Growth Factors
- Fibroblast Growth Factor-23
- Alkaline Phosphatase
- Calcitriol
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Topics |
- Adult
- Alkaline Phosphatase
(blood)
- Biomarkers
(blood)
- Biomarkers, Tumor
(blood)
- Bone and Bones
(metabolism)
- Calcitriol
(blood)
- Ergocalciferols
(blood)
- Familial Hypophosphatemic Rickets
(blood)
- Female
- Fibroblast Growth Factor-23
- Fibroblast Growth Factors
(blood)
- Genetic Diseases, X-Linked
- Humans
- Male
- Middle Aged
- Neoplasms, Connective Tissue
(blood)
- Osteomalacia
(blood)
- Paraneoplastic Syndromes
- Peptide Fragments
(blood)
- Procollagen
(blood)
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