Olopatadine 0.6% nasal spray protects from vasomotor challenge in patients with severe vasomotor rhinitis.

Abstract

BACKGROUND:

Vasomotor rhinitis (VMR) is a hypersensitivity syndrome with heightened reactivity to environmental triggers.

METHODS:

Twenty-two patients with severe VMR were treated nasally with either normal saline or 0.6% olopatadine and challenged nasally with a hyperosmolar mannitol solution.

RESULTS:

Treatment with 0.6% olopatadine resulted in an improvement in instantaneous nasal symptom scores at 5 and 30 minutes (p < 0.01) compared with baseline and at 30 minutes after hyperosmolar challenge compared with saline-pretreated individuals (p < 0.01). There was also an improvement in nasal peak inspiratory flow rate at 30 minutes after hyperosmolar challenge compared with saline-pretreated individuals (p < 0.01).

CONCLUSION:

In this patient population 0.6% olopatadine appears to be efficacious in symptom reduction in VMR and protects from hyperosmolar challenge.

• Authors: Peter K Smith, Joel Collins
• Journal: American journal of rhinology & allergy (Am J Rhinol Allergy) 2011 Jul-Aug Vol. 25 Issue 4 Pg. e149-52 ISSN: 1945-8932 [Electronic] United States
• PMID: 21819751 (Publication Type: Journal Article)

Chemical References

• Dibenzoxepins
• Nasal Sprays
• Olopatadine Hydrochloride
• Capsaicin

Topics

• Adolescent
• Adult
• Aged
• Capsaicin (administration & dosage)
• Dibenzoxepins (administration & dosage, adverse effects)
• Disease Progression
• Female
• Humans
• Inspiratory Capacity (drug effects)
• Male
• Middle Aged
• Nasal Obstruction (prevention & control)
• Nasal Provocation Tests
• Nasal Sprays
• Olopatadine Hydrochloride
• Rhinitis, Vasomotor (diagnosis, drug therapy, physiopathology)