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Ampicillin/sulbactam versus clindamycin in the treatment of postpartum endomyometritis.

Abstract
Sixty-eight patients with postpartum endomyometritis were enrolled in this open randomized comparative study. Forty-two patients received ampicillin/sulbactam and 26 received clindamycin. The cure rates were similar in the two groups: 83% in the ampicillin/sulbactam group and 88% in the clindamycin group. The most frequent endometrial bacterial isolates were Bacteroides bivius, Streptococcus faecalis, Escherichia coli, and Ureaplasma urealyticum. Bacteremia was present in 15 of 68 (22%), the most frequent isolates being Mycoplasma (four cases) and B bivius (three cases). Clindamycin-resistant species were S faecalis, E coli, and Proteus mirabilis. There were seven treatment failures in the ampicillin/sulbactam group; only one isolate (an E coli) was resistant to ampicillin/sulbactam. In a significant number of these failures, Mycoplasma was isolated. Ampicillin/sulbactam and clindamycin were found to be equally efficacious in the treatment of postpartum endometritis.
AuthorsM G Martens, S Faro, H A Hammill, D Smith, G Riddle, M Maccato
JournalSouthern medical journal (South Med J) Vol. 83 Issue 4 Pg. 408-13 (Apr 1990) ISSN: 0038-4348 [Print] United States
PMID2181689 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Clindamycin
  • Ampicillin
  • Sulbactam
Topics
  • Adult
  • Ampicillin (administration & dosage, therapeutic use)
  • Ampicillin Resistance
  • Bacteria (drug effects, isolation & purification)
  • Bacterial Infections (diagnosis, drug therapy)
  • Clindamycin (therapeutic use)
  • Drug Administration Schedule
  • Drug Evaluation
  • Drug Resistance, Microbial
  • Drug Therapy, Combination (therapeutic use)
  • Endometritis (diagnosis, drug therapy)
  • Female
  • Humans
  • Infusions, Intravenous
  • Puerperal Infection (diagnosis, drug therapy)
  • Randomized Controlled Trials as Topic
  • Sulbactam (administration & dosage, therapeutic use)

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