Abstract |
Sixty-eight patients with postpartum endomyometritis were enrolled in this open randomized comparative study. Forty-two patients received ampicillin/sulbactam and 26 received clindamycin. The cure rates were similar in the two groups: 83% in the ampicillin/sulbactam group and 88% in the clindamycin group. The most frequent endometrial bacterial isolates were Bacteroides bivius, Streptococcus faecalis, Escherichia coli, and Ureaplasma urealyticum. Bacteremia was present in 15 of 68 (22%), the most frequent isolates being Mycoplasma (four cases) and B bivius (three cases). Clindamycin-resistant species were S faecalis, E coli, and Proteus mirabilis. There were seven treatment failures in the ampicillin/sulbactam group; only one isolate (an E coli) was resistant to ampicillin/sulbactam. In a significant number of these failures, Mycoplasma was isolated. Ampicillin/sulbactam and clindamycin were found to be equally efficacious in the treatment of postpartum endometritis.
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Authors | M G Martens, S Faro, H A Hammill, D Smith, G Riddle, M Maccato |
Journal | Southern medical journal
(South Med J)
Vol. 83
Issue 4
Pg. 408-13
(Apr 1990)
ISSN: 0038-4348 [Print] United States |
PMID | 2181689
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Clindamycin
- Ampicillin
- Sulbactam
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Topics |
- Adult
- Ampicillin
(administration & dosage, therapeutic use)
- Ampicillin Resistance
- Bacteria
(drug effects, isolation & purification)
- Bacterial Infections
(diagnosis, drug therapy)
- Clindamycin
(therapeutic use)
- Drug Administration Schedule
- Drug Evaluation
- Drug Resistance, Microbial
- Drug Therapy, Combination
(therapeutic use)
- Endometritis
(diagnosis, drug therapy)
- Female
- Humans
- Infusions, Intravenous
- Puerperal Infection
(diagnosis, drug therapy)
- Randomized Controlled Trials as Topic
- Sulbactam
(administration & dosage, therapeutic use)
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