Abstract | AIM: METHODS: This is a prospective controlled study, and a total of 53 hepatitis B e antigen ( HBeAg)-positive patients with viral rebound but without resistance were received either LAM plus ADV or LAM alone treatment. RESULTS: After 1-year treatment, more patients who received LAM plus ADV than those who received LAM alone had ALT normalization (84% versus 53.6%, P = 0.018) or HBV DNA levels below 1000 copies/mL (80% versus 42.9%, P < 0.006). Seven patients receiving LAM plus ADV had HBeAg seroconversion, as compared with 0 in patients receiving ALM alone (28% versus 0%, P = 0.003). During 1-year retreatment, five patients receiving LAM alone had virological breakthrough and all of them had LAM resistance strains (rtM204V/I), while no LAM- or ADV- associated resistance strains were detected in patients receiving LAM plus ADV. All patients receiving LAM plus ADV were well tolerated, and no serious side effects were noted. CONCLUSIONS: Patients treated with LAM plus ADV exhibited significantly greater virological, biochemical and serological responses compared with LAM alone. These data suggested that combination of LAM plus ADV would be a good option for the retreatment of CHB patients with viral relapse after cessation of LAM.
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Authors | Zhao Wang, Xiao-Ling Wu, Wei-Zheng Zeng, Hui Xu, Yong Zhang, Jian-Ping Qin, Ming-De Jiang |
Journal | Virology journal
(Virol J)
Vol. 8
Pg. 388
(Aug 04 2011)
ISSN: 1743-422X [Electronic] England |
PMID | 21816062
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antiviral Agents
- Organophosphonates
- Lamivudine
- adefovir
- Adenine
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Topics |
- Adenine
(administration & dosage, adverse effects, analogs & derivatives)
- Adult
- Antiviral Agents
(administration & dosage, adverse effects)
- Drug Therapy, Combination
(adverse effects, methods)
- Female
- Hepatitis B, Chronic
(drug therapy)
- Humans
- Lamivudine
(administration & dosage, adverse effects)
- Male
- Organophosphonates
(administration & dosage, adverse effects)
- Prospective Studies
- Recurrence
- Salvage Therapy
(adverse effects, methods)
- Treatment Outcome
- Withholding Treatment
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