Intra-articular injection of hyaluronic acid (MW 1,500-2,000 kDa; HyalOne) in symptomatic osteoarthritis of the hip: a prospective cohort study.

Abstract

INTRODUCTION:

Clinical trials have demonstrated the safety and efficacy of hyaluronic acid-based products for the treatment of hip osteoarthritis, but data from observational studies of normal medical practice are scarce. This study investigated the long-term efficacy and tolerability of ultrasound-guided intra-articular sodium hyaluronate (MW 1,500-2,000 kDa; Hyalone) injections in daily clinical practice.

METHODS:

In this observational, cohort study of patients with hip osteoarthritis, Hyalone was administered under the ultrasound guidance, every 6 months, with the possibility of an additional injection at the intervening 3-month intervals on clinical request. Efficacy measurements included the Lequesne algofunctional index, self-reported pain via the visual analogue scale (VAS), the concomitant use of non-steroidal anti-inflammatory drugs (NSAIDs) and safety. The patients were followed up for 18 months after the first intra-articular injection.

RESULTS:

Data from 120 patients were collected. During the study, a statistically significant reduction in algofunctional indexes was demonstrated at 3 months after study product injection, while at 12 months 80% of the patients achieved a decrease of at least 30% in symptoms. These results were maintained over time through cyclical and personalized repetition of ultrasound guided injections, at least one injection every 6 months.

CONCLUSIONS:

The study treatment reduced pain and improved mobility in osteoarthritis of the hip. These results in daily clinical practice demonstrate a beneficial effect and the safety of the study product and suggest adding intra-articular injections of HyalOne to the armamentarium of conservative management of symptomatic hip osteoarthritis.

• Authors: Alberto Migliore, Migliore Alberto, Umberto Massafra, Massafra Umberto, Emanuele Bizzi, Bizzi Emanuele, Bruno Lagana, Laganà Bruno, Valentina Germano, Germano Valentina, Prisco Piscitelli, Piscitelli Prisco, Mauro Granata, Granata Mauro, Sandro Tormenta, Tormenta Sandro
• Journal: Archives of orthopaedic and trauma surgery (Arch Orthop Trauma Surg) Vol. 131 Issue 12 Pg. 1677-85 (Dec 2011) ISSN: 1434-3916 [Electronic] Germany
• PMID: 21814776 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Viscosupplements
• Hyaluronic Acid

Topics

• Cohort Studies
• Female
• Humans
• Hyaluronic Acid (administration & dosage)
• Injections, Intra-Articular
• Male
• Middle Aged
• Molecular Weight
• Osteoarthritis, Hip (complications, drug therapy)
• Prospective Studies
• Viscosupplements (administration & dosage)