Intra-arterial nicardipine for the treatment of cerebral vasospasm in postpartum cerebral angiopathy: a case study and review of literature.

Abstract

INTRODUCTION:

Postpartum cerebral angiopathy is one of the many neurological complications seen during pregnancy and the postpartum period. Management of these patients consists of optimal blood pressure control, and general supportive critical care. We present a case of diffuse cerebral vasospasm, which improved with intra-arterial nicardipine. This brief report addresses the utility of interventional management in cases of postpartum cerebral angiopathy.

CASE REPORT:

A 28-year-old female presented 1 week after cesarean delivery with altered mental status, endotracheal intubation for airway protection, thrombocytopenia, and hypofibrinogenemia. Cerebral angiogram revealed anterior and posterior circulation vasospasm, which responded to repeated selective intra-arterial injections of nicardipine. This treatment coupled with optimal blood pressure control resulted in complete recovery.

DISCUSSION:

Our case report highlights the importance of cerebral angiography for the diagnosis and treatment of patients with postpartum cerebral angiopathy. Although nicardipine is used in patients with aneurysmal subarachnoid hemorrhage for the treatment of cerebral vasospasm, this agent has the potential to be used in patients with cerebral vasospasm due to other etiologies.

SUMMARY:

Intra-arterial nicardipine is one of the therapeutic measures available to physicians in the management of patients with cerebral vasospasm. In patients with postpartum cerebral angiopathy, early cerebral angiography should be considered to quantify and treat cerebral vasospasm with either angioplasty or selective intra-arterial injections of nicardipine.

• Authors: Abhijit Lele, Timothy Lyon, Ania Pollack, Kathrin Husmann, Alan Reeves
• Journal: The International journal of neuroscience (Int J Neurosci) Vol. 121 Issue 10 Pg. 537-42 (Oct 2011) ISSN: 1563-5279 [Electronic] England
• PMID: 21812738 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Vasodilator Agents
• Nicardipine

Topics

• Adult
• Brain (diagnostic imaging, pathology)
• Female
• Humans
• Injections, Intra-Arterial (methods)
• Magnetic Resonance Angiography
• Magnetic Resonance Imaging
• Nicardipine (administration & dosage)
• Postpartum Period
• Pregnancy
• Tomography, X-Ray Computed
• Ultrasonography, Doppler, Transcranial
• Vasodilator Agents (administration & dosage)
• Vasospasm, Intracranial (diagnostic imaging, drug therapy, pathology)