Abstract | BACKGROUND: METHODS AND RESULTS: Anesthetized rabbits were submitted to either 5 or 10 minutes of untreated ventricular fibrillation. After cardiopulmonary resuscitation and resumption of a spontaneous circulation, the animals underwent either normothermic life support (control) or therapeutic hypothermia induced by TLV. The latter procedure decreased esophageal and tympanic temperatures to 32°C to 33°C within only 10 minutes. After rewarming, the animals submitted to TLV exhibited an attenuated neurological dysfunction and decreased mortality 7 days later compared with control. The neuroprotective effect of TLV was confirmed by a significant reduction in brain histological damages. We also observed limitation of myocardial necrosis, along with a decrease in troponin I release and a reduced myocardial caspase 3 activity, with TLV. The beneficial effects of TLV were directly related to the rapidity of hypothermia induction because neither conventional cooling (cold saline infusion plus external cooling) nor normothermic TLV elicited a similar protection. CONCLUSIONS:
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Authors | M Chenoune, F Lidouren, C Adam, S Pons, L Darbera, P Bruneval, B Ghaleh, R Zini, J-L Dubois-Randé, P Carli, B Vivien, J-D Ricard, A Berdeaux, R Tissier |
Journal | Circulation
(Circulation)
Vol. 124
Issue 8
Pg. 901-11, 1-7
(Aug 23 2011)
ISSN: 1524-4539 [Electronic] United States |
PMID | 21810660
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Cardiopulmonary Resuscitation
- Disease Models, Animal
- Fluorocarbons
- Heart
(physiology)
- Heart Arrest
(mortality, physiopathology, therapy)
- Hypothermia, Induced
(methods)
- Kidney
(physiology)
- Liquid Ventilation
- Liver
(physiology)
- Lung
(physiology)
- Nervous System Physiological Phenomena
- Rabbits
- Reperfusion Injury
(mortality, physiopathology, prevention & control)
- Time Factors
- Ventricular Fibrillation
(mortality, physiopathology, therapy)
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