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Adult granulosa cell tumor associated with endometrial carcinoma: a case report.

AbstractINTRODUCTION:
If strict criteria for the diagnosis of carcinoma are used and all patients with granulosa cell tumors are considered, the best estimate of the incidence of associated endometrial carcinomas is under 5%. In patients with granulosa cell tumors, estrogen-dependent endometrial cancers are rarely found, and most of these endometrial cancers are well-differentiated endometrioid adenocarcinomas that carry a good prognosis when detected early.
CASE PRESENTATION:
We report the case of a 65-year-old post-menopausal Nigerian woman of the Igbo tribe with an adult granulosa cell tumor that was initially treated as endometrial carcinoma. She underwent a total abdominal hysterectomy and a bilateral salpingo-oophorectomy after histopathologic confirmation of a well-differentiated granulosa cell tumor of the ovary and a nuclear grade 1 adenocarcinoma of the endometrium (International Federation of Obstetricians and Gynecologists stage 1B). She had a good post-operative recovery and was discharged 10 days after treatment.
CONCLUSION:
The association between adult granulosa cell tumors of the ovary and endometrial carcinomas is rare. A high index of suspicion as well as good imaging and histopathologic analyses are important in making this diagnosis.
AuthorsCornelius O Ukah, Okechukwu C Ikpeze, George U Eleje, Ahizechukwu C Eke
JournalJournal of medical case reports (J Med Case Rep) Vol. 5 Pg. 340 (Aug 02 2011) ISSN: 1752-1947 [Electronic] England
PMID21810262 (Publication Type: Journal Article)

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