Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: AIM OF THE STUDY: This study aimed to assess the anti-inflammatory and anti-nociceptive activity of the water extract from Sipunculus nudus. MATERIALS AND METHODS: The water extract from the body wall of Sipunculus nudus was obtained with the yield of 14.1%. The anti-inflammatory effect in six animal models and anti-nociceptive effect in two animal models of the water extract were evaluated by oral for the study. RESULTS: Pretreatment with the extract (at the dose of 50, 100 and 200 mg/kg) produced significant dose-dependent anti-inflammatory and anti-nociceptive effects. At 200 mg/kg dose, the inhibition ratio of the extract on carrageenan-induced rat hind paw oedema, dextran-induced rat paw oedema, cotton pellet granuloma in rats, carrageenan-induced peritonitis and acetic acid-induced vascular permeability were 59.2%, 51.0%, 53.1%, 42.5%, 50.8%, better than that of indomethacin (5 mg/kg) 49.5%, 50%, 44.4%, 37.6%, 46.8%, respectively. The inhibition ratio of the extract (200 mg/kg dose) on xylene-induced mouse ear oedema was 61.5%, lower than 63.7% for indomethacin (5 mg/kg). At 200mg/kg, the extract decreased number of writhing 52.3% in acetic acid-induced writhing model and increased the response latency 25.24% in hot plate test. CONCLUSIONS: The water extract from the body wall of Sipunculus nudus possesses excellent anti-inflammatory activity as well as peripheral and central analgesic properties.
|
Authors | Chen-Xiao Zhang, Zi-Ru Dai, Qiu-Xing Cai |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 137
Issue 3
Pg. 1177-82
(Oct 11 2011)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 21807085
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Analgesics
- Anti-Inflammatory Agents
- Dextrans
- Xylenes
- Carrageenan
- Acetic Acid
|
Topics |
- Acetic Acid
- Administration, Oral
- Analgesics
(administration & dosage, isolation & purification, pharmacology)
- Animals
- Anti-Inflammatory Agents
(administration & dosage, isolation & purification, pharmacology)
- Capillary Permeability
(drug effects)
- Carrageenan
- Cotton Fiber
- Dextrans
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Edema
(chemically induced, prevention & control)
- Granuloma, Foreign-Body
(etiology, prevention & control)
- Medicine, Chinese Traditional
- Mice
- Motor Activity
(drug effects)
- Nematoda
(chemistry)
- Organotherapy
- Pain
(chemically induced, physiopathology, prevention & control)
- Pain Threshold
(drug effects)
- Peritonitis
(chemically induced, prevention & control)
- Rats
- Rats, Wistar
- Xylenes
|