Evaluation of crosslinked and non-crosslinked biologic prostheses for abdominal hernia repair.

Abstract

INTRODUCTION:

Abdominal wall defects and incisional hernias represent a challenging problem. Currently, several commercially available biologic prostheses are used clinically for hernia repair. We compared the performance and efficacy of two non-crosslinked meshes in ventral hernia repair to two crosslinked prostheses in a rodent model.

METHODS:

Animals were divided into 12 groups (4 matrix types and 3 termination time-points per matrix). A ventral defect was carefully created and overlapped with the biologic prosthesis.

RESULTS:

Major complications were seroma induction (3 mesh types), implant extrusion (1 mesh type), severe inflammatory and immune responses (non-crosslinked mesh), fibrosis and mineralisation (3 mesh types). After inflammation resolution, 3 of the matrices tested supported hernia healing but with marked tissue and temporal differences. AlloDerm(®*) and Surgisis Gold™ showed tissue reactivity with the host and a rapid rate of matrix remodelling. Bard CollaMend™(*) Implant proved to be inept for hernia repair under the conditions tested. Permacol™ biological implant integration with host tissue increased over time, supporting hernia healing with strength of tissue, and appears to be a safe prosthetic material for ventral hernia repair based on the results of this rodent study.

• Authors: L E de Castro Brás, S Shurey, P D Sibbons
• Journal: Hernia : the journal of hernias and abdominal wall surgery (Hernia) Vol. 16 Issue 1 Pg. 77-89 (Feb 2012) ISSN: 1248-9204 [Electronic] France
• PMID: 21805341 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alloderm
• Biocompatible Materials
• Permacol
• Collagen

Topics

• Abdominal Wall (pathology)
• Animals
• Biocompatible Materials (adverse effects)
• Collagen (adverse effects, therapeutic use)
• Fibrosis
• Hernia, Ventral (surgery)
• Herniorrhaphy (adverse effects)
• Inflammation (etiology, pathology)
• Male
• Materials Testing
• Prosthesis Failure
• Rats
• Rats, Sprague-Dawley
• Seroma (etiology)
• Surgical Mesh (adverse effects)
• Tensile Strength
• Time Factors