Abstract | OBJECTIVES: To review the available evidence for the efficacy and safety of non-steroidal anti-inflammatory drugs ( NSAIDs), synthetic and biological drug therapies for the different clinical manifestations of psoriatic arthritis (PsA) in order to provide data for the development of treatment recommendations by the European League Against Rheumatism (EULAR) taskforce. METHODS: A systematic literature review (SLR) of available treatments for PsA was performed using the largest electronic databases (MEDLINE, EMBASE and COCHRANE) by two working groups formed within the EULAR taskforce. This comprised a comprehensive sample of rheumatologists, dermatologists, epidemiologists and patients. The available evidence was reviewed for NSAIDs, synthetic disease modifying antirheumatic drugs (DMARDs), local and systemic corticosteroids and biologic drugs. All articles and abstracts published between 1962 and January 2010 were reviewed and considered and a meta-analysis of data on biological therapies was performed. RESULTS: CONCLUSIONS: This SLR reveals some evidence to support the use of NSAIDs and synthetic DMARDs and good evidence for the efficacy of anti-TNF therapy in PsA.
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Authors | Zoe Ash, Cécile Gaujoux-Viala, Laure Gossec, Elizabeth M A Hensor, Oliver FitzGerald, Kevin Winthrop, Désirée van der Heijde, Paul Emery, Josef S Smolen, Helena Marzo-Ortega |
Journal | Annals of the rheumatic diseases
(Ann Rheum Dis)
Vol. 71
Issue 3
Pg. 319-26
(Mar 2012)
ISSN: 1468-2060 [Electronic] England |
PMID | 21803753
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Biological Products
- Tumor Necrosis Factor-alpha
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Topics |
- Anti-Inflammatory Agents, Non-Steroidal
(adverse effects, therapeutic use)
- Antirheumatic Agents
(adverse effects, therapeutic use)
- Arthritis, Psoriatic
(drug therapy)
- Biological Products
(adverse effects, therapeutic use)
- Evidence-Based Medicine
(methods)
- Humans
- Practice Guidelines as Topic
- Treatment Outcome
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors)
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