Immunoglobulin E receptor signaling and asthma.

Abstract

Elevated IgE levels and increased IgE sensitization to allergens are central features of allergic asthma. IgE binds to the high-affinity Fcε receptor I (FcεRI) on mast cells, basophils, and dendritic cells and mediates the activation of these cells upon antigen-induced cross-linking of IgE-bound FcεRI. FcεRI activation proceeds through a network of signaling molecules and adaptor proteins and is negatively regulated by a number of cell surface and intracellular proteins. Therapeutic neutralization of serum IgE in moderate-to-severe allergic asthmatics reduces the frequency of asthma exacerbations through a reduction in cell surface FcεRI expression that results in decreased FcεRI activation, leading to improved asthma control. Our increasing understanding of IgE receptor signaling may lead to the development of novel therapeutics for the treatment of asthma.

• Authors: Lawren C Wu
• Journal: The Journal of biological chemistry (J Biol Chem) Vol. 286 Issue 38 Pg. 32891-7 (Sep 23 2011) ISSN: 1083-351X [Electronic] United States
• PMID: 21799019 (Publication Type: Journal Article, Review)

Chemical References

• Receptors, IgE

Topics

• Asthma (immunology, therapy)
• Calcium Signaling (immunology)
• Cell Membrane (immunology)
• Humans
• Lipid Metabolism (immunology)
• Receptors, IgE (immunology)
• Signal Transduction (immunology)