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A randomized trial of 1- and 3-month depot leuprolide doses in the treatment of central precocious puberty.

AbstractOBJECTIVE:
To compare 1-month and 3-month depot formulations of leuprolide acetate (DL), a gonadotropin-releasing hormone analog, in the treatment of central precocious puberty (CPP).
STUDY DESIGN:
Subjects with CPP naïve to therapy were randomized to 7.5 mg of 1-month DL, 11.25 mg of 3-month DL, or 22.5 mg of 3-month DL. Stimulated luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and estradiol levels, growth velocity, and bone age progression were examined in a 2-year period.
RESULTS:
Forty-nine female and 5 male subjects with CPP were randomized. Mean stimulated LH and FSH levels during treatment were higher in the low-dose 11.25-mg 3-month DL group, and more LH levels >4 IU/L were observed, in comparison with the other two dose groups. Mean LH and FSH levels in the 22.5-mg 3-month group were not different from the monthly DL. No differences in estradiol levels, growth velocity, or bone age progression were observed in dosing groups.
CONCLUSIONS:
All DL doses resulted in prompt and effective suppression of puberty, but higher LH and FSH levels were seen with the 11.25-mg 3-month DL dose. Multi-monthly DL is effective in treating CPP, but higher dosing may be required in some circumstances.
AuthorsKimberly Fuld, Carolyn Chi, E Kirk Neely
JournalThe Journal of pediatrics (J Pediatr) Vol. 159 Issue 6 Pg. 982-7.e1 (Dec 2011) ISSN: 1097-6833 [Electronic] United States
PMID21798557 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Mosby, Inc. All rights reserved.
Chemical References
  • Delayed-Action Preparations
  • Leuprolide
Topics
  • Child
  • Delayed-Action Preparations
  • Drug Administration Schedule
  • Female
  • Humans
  • Leuprolide (administration & dosage)
  • Male
  • Puberty, Precocious (drug therapy)
  • Time Factors

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