Abstract | OBJECTIVE: STUDY DESIGN: RESULTS: Forty-nine female and 5 male subjects with CPP were randomized. Mean stimulated LH and FSH levels during treatment were higher in the low-dose 11.25-mg 3-month DL group, and more LH levels >4 IU/L were observed, in comparison with the other two dose groups. Mean LH and FSH levels in the 22.5-mg 3-month group were not different from the monthly DL. No differences in estradiol levels, growth velocity, or bone age progression were observed in dosing groups. CONCLUSIONS: All DL doses resulted in prompt and effective suppression of puberty, but higher LH and FSH levels were seen with the 11.25-mg 3-month DL dose. Multi-monthly DL is effective in treating CPP, but higher dosing may be required in some circumstances.
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Authors | Kimberly Fuld, Carolyn Chi, E Kirk Neely |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 159
Issue 6
Pg. 982-7.e1
(Dec 2011)
ISSN: 1097-6833 [Electronic] United States |
PMID | 21798557
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Mosby, Inc. All rights reserved. |
Chemical References |
- Delayed-Action Preparations
- Leuprolide
|
Topics |
- Child
- Delayed-Action Preparations
- Drug Administration Schedule
- Female
- Humans
- Leuprolide
(administration & dosage)
- Male
- Puberty, Precocious
(drug therapy)
- Time Factors
|