Usefulness of pre-operative copeptin concentrations to predict post-operative outcome after major vascular surgery.

Abstract

The aim of this study was to investigate whether preoperative determination of plasma copeptin levels in addition to plasma N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) could help improve risk stratification in patients who undergo major vascular surgery. One hundred ninety-eight consecutive patients who underwent major vascular surgery (58.6% infrainguinal aortic reconstruction, 23.7% abdominal aortic aneurysm surgery, 17.7% carotid endarterectomy) were included in this study. Patients were monitored for in-hospital and long-term (2-years) major adverse cardiac events, consisting of cardiac death, nonfatal myocardial infarction, and emergent coronary revascularization. Overall, 40 patients (20.2%) reached the primary end point, and most of these events occurred during the index hospital stay (n = 18 [45%]). In univariate Cox regression analysis, increasing concentrations of copeptin were significant determinants of outcome as a continuous variable (hazard ratio [HR] 1.012, p = 0.005) and as a dichotomized variable according to the recommended cutoff of 14.0 pmol/L (HR 4.116, p <0.001). Subgroup analyses revealed that especially patients at low estimated risk according to plasma NT-pro-BNP levels were at significantly higher risk for worse outcomes with higher copeptin levels (HR 5.983, p = 0.002). In multivariate Cox regression analysis, copeptin concentrations >14 pmol/L were significant independent predictors of outcome (HR 2.842, p = 0.002) in addition to type of surgery, history of myocardial infarction, elevated levels of cardiac troponin T, and NT-pro-BNP levels. In conclusion, the results of this study suggest that preoperative determination of this new biomarker could substantially improve prediction of perioperative and postoperative outcomes in vascular surgery patients.

• Authors: Rudolf Jarai, Elisabeth Mahla, Thomas Perkmann, Robert Jarai, Sylvia Archan, Ioannis Tentzeris, Kurt Huber, Helfried Metzler
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 108 Issue 8 Pg. 1188-95 (Oct 15 2011) ISSN: 1879-1913 [Electronic] United States
• PMID: 21798504 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Glycopeptides
• Protein Precursors
• copeptins

Topics

• Aged
• Austria (epidemiology)
• Biomarkers (blood)
• Female
• Follow-Up Studies
• Glycopeptides (blood)
• Humans
• Incidence
• Male
• Postoperative Complications (blood, epidemiology)
• Predictive Value of Tests
• Preoperative Care (methods)
• Prevalence
• Prognosis
• Prospective Studies
• Protein Precursors
• Risk Assessment (methods)
• Vascular Diseases (blood, surgery)
• Vascular Surgical Procedures