Abstract | BACKGROUND: METHODS: Saliva was collected from healthy children, pretreatment oncology patients, neutropenic patients on treatment with no oral disease and mucositic patients. TFF1, 2 and 3 were quantified using ELISA. RESULTS: In healthy children TFF2 and 3 were positively correlated with age (r = 0.454, p = 0.01 for TFF2; r = 0.410, p = 0.05 for TFF3 Spearman rank correlation). TFF3 was higher in mucositis compared to all other groups. A linear regression prediction model indicated that TFF3, but not TFF1 and TFF2, was significantly different in mucositic and healthy controls, suggesting an altered pattern of trefoil peptide secretion (p = 0.021). CONCLUSIONS: This study is the first to focus on trefoil peptides in paediatric saliva. It shows the correlation between TFF2, TFF3 and age in healthy children. Paediatric mucositis disease occurs in the presence of increased concentrations and an altered pattern of trefoil peptides.
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Authors | Fran Verey, Ebba Nexo, Rosemary Greenwood, Monica Berry, Anthony P Corfield |
Journal | Clinical chemistry and laboratory medicine
(Clin Chem Lab Med)
Vol. 49
Issue 12
Pg. 2051-5
(Dec 2011)
ISSN: 1437-4331 [Electronic] Germany |
PMID | 21793798
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Peptides
- TFF1 protein, human
- TFF2 protein, human
- TFF3 protein, human
- Trefoil Factor-1
- Trefoil Factor-2
- Trefoil Factor-3
- Tumor Suppressor Proteins
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Topics |
- Adolescent
- Child
- Child, Preschool
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Infant
- Male
- Mucositis
(metabolism, pathology)
- Peptides
(analysis)
- Saliva
(metabolism)
- Trefoil Factor-1
- Trefoil Factor-2
- Trefoil Factor-3
- Tumor Suppressor Proteins
(analysis)
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