HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Long-term variability of desmosine/isodesmosine as biomarker in alpha-1-antritrypsin deficiency-related COPD.

Abstract
Desmosine and isodesmosine are products of elastin breakdown which are candidate biomarkers to measure lung destruction in COPD. Data exist on the burden of desmosines in urine and plasma in COPD but long-term changes have never been investigated. We determined the changes of desmosine levels over 14 months in urine and plasma of patients with type ZZ alpha-1-antitryspsin deficiency-related COPD. Urines and plasma for determination of desmosines were collected from 11 ex-smokers with moderate/severe emphysema at monthly intervals for 14 months. Spirometry and gas transfer were assessed at baseline and 6-month intervals. At baseline and month 14, eleven healthy partners of patients volunteered to give a blood sample for detection of desmosines. Desmosines were determined by capillary electrophoresis combined with laser-induced fluorescence. Urine and plasma desmosines were significantly increased after 14 months in patients (p = 0.027 and p = 0.0005, respectively). Plasma desmosines of healthy partners at baseline were 4-fold lower than from patients and not significantly different from values at month 14. Only a significant decline in lung gas transfer occurred in patients (p = 0.015). The variability of desmosines was higher in urine than in plasma (coefficient of variation 0.17 and 0.087, respectively). As longitudinal desmosine changes likely reflect the elevated elastic fiber turnover associated with the progression of lung damage and destruction in COPD, they appear to be a suitable marker for application in long-term studies. Plasma desmosines were more stable long-term biomarkers than desmosines in urine.
AuthorsLaura Fregonese, Fabio Ferrari, Marco Fumagalli, Maurizio Luisetti, Jan Stolk, Paolo Iadarola
JournalCOPD (COPD) Vol. 8 Issue 5 Pg. 329-33 (Oct 2011) ISSN: 1541-2563 [Electronic] England
PMID21793711 (Publication Type: Journal Article)
Chemical References
  • Biomarkers
  • SERPINA1 protein, human
  • alpha 1-Antitrypsin
  • Desmosine
  • Isodesmosine
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers (blood, urine)
  • Desmosine (blood, urine)
  • Female
  • Forced Expiratory Volume
  • Humans
  • Isodesmosine (blood, urine)
  • Male
  • Middle Aged
  • Pulmonary Emphysema (metabolism, physiopathology)
  • Time Factors
  • alpha 1-Antitrypsin (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: