Botulinum toxin type A in patients with Parkinson's disease and refractory overactive bladder.

Abstract

PURPOSE:

In this 6-month followup study we investigated the effect of intradetrusor injection of 100 U botulinum toxin type A in patients with Parkinson's disease and refractory detrusor overactivity.

MATERIALS AND METHODS:

Eight patients with Parkinson's disease and detrusor overactivity refractory to anticholinergics were injected with 100 U botulinum toxin type A. Daytime and nighttime urinary frequency, and urinary incontinence episodes were recorded. Patients also completed a standardized quality of life questionnaire on incontinence and a visual analog scale on the impact of bladder problems on daily life activities, and underwent urodynamic assessment, including pressure flow studies. Clinical and urodynamic assessment was performed before, and 1, 3 and 6 months after injection.

RESULTS:

In all patients 100 U botulinum toxin type A induced decreased daytime and nighttime urinary frequency, a decreased number of urinary incontinence episodes, increased quality of life scores and, as shown by increased maximum cystometric capacity, improved urodynamic findings. In 2 patients with Parkinson's disease post-void residual urine volume developed.

CONCLUSIONS:

Intradetrusor injection of 100 U botulinum toxin type A induced clinical and urodynamic improvement in overactive bladder symptoms that lasted at least 6 months in patients with Parkinson's disease.

• Authors: Antonella Giannantoni, Antonella Conte, Silvia Proietti, Silvia Giovannozzi, Aroldo Rossi, Giovanni Fabbrini, Massimo Porena, Alfredo Berardelli
• Journal: The Journal of urology (J Urol) Vol. 186 Issue 3 Pg. 960-4 (Sep 2011) ISSN: 1527-3792 [Electronic] United States
• PMID: 21791351 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Chemical References

• Neuromuscular Agents
• Botulinum Toxins, Type A

Topics

• Aged
• Botulinum Toxins, Type A (therapeutic use)
• Female
• Follow-Up Studies
• Humans
• Male
• Neuromuscular Agents (therapeutic use)
• Parkinson Disease (complications)
• Time Factors
• Urinary Bladder, Overactive (drug therapy, etiology)