[Malonaldehyde and tumor necrosis factor-alpha as indicators of intoxication syndrome in erysipelatous inflammation].

Abstract

The aim of the investigation was to study the implication of infectious endotoxicosis in the pathogenesis of erysipelas, by measuring the level of malondialdehyde and the proinflammatory cytokine tumor necrosis factor-a (TNF-a) depending on the stage, severity, pattern of the disease, and possible complications. Fifty-six patients with erysipelas were followed up. Their blood level of malondialdehyde and TNF-a was determined at the height of the disease and during the reduction of clinical symptoms, and early convalescence. There was an increase in the study indicators, which depended on the period and severity of the disease and the presence of comorbidity and complications. The changes found in the study indicators characterize the development of intoxication syndrome in erysipelas and make possible their use to evaluate the severity of the diseases, the presence of complications, and the completeness of recovery.

• Authors: M Iu Marzhokhova, M M Afashagova, A R Marzhokhova
• Journal: Klinicheskaia laboratornaia diagnostika (Klin Lab Diagn) Issue 5 Pg. 20-2 (May 2011) ISSN: 0869-2084 [Print] Russia (Federation)
• PMID: 21789799 (Publication Type: English Abstract, Journal Article)

Chemical References

• Biomarkers
• Endotoxins
• Tumor Necrosis Factor-alpha
• Malondialdehyde

Topics

• Biomarkers (blood)
• Disease Progression
• Endotoxins (adverse effects)
• Erysipelas (diagnosis, etiology, physiopathology)
• Erythema
• Female
• Follow-Up Studies
• Humans
• Inflammation
• Lipid Peroxidation
• Male
• Malondialdehyde (blood)
• Recurrence
• Tumor Necrosis Factor-alpha (blood)