Abstract | BACKGROUND AND AIM: PATIENTS AND METHODS: Thirty-nine children and adolescents with IBD (24 with Crohn disease [CD] and 15 with ulcerative colitis [UC]) and 25 healthy controls were enrolled in the study. VEGF and TGF-β1 were assessed at the baseline and after 2 and 4 weeks of EEN in CD and UC groups and once in controls using enzyme-linked immunosorbent assay immunoassays. RESULTS: At the baseline, we found increased serum VEGF in the CD versus UC group and controls (P < 0.05) and serum TGF-β1 in the UC versus CD group and controls (P < 0.05). During EEN, VEGF decreased in the UC and CD groups, whereas TGF-β1 increased in the CD group and decreased in the UC group. The CD group achieved disease remission faster than the UC group, and the weight gain of patients with CD during EEN was higher compared with patients with UC. Additionally, TGF-β1 concentration correlated with protein and energies daily intake in the CD group (R = 0.95; P < 0.05). CONCLUSIONS: Different effectiveness of EEN in achieving remission in CD and UC may result from a modification of growth factor production. EEN stimulated TGF-β1 production in CD but not in UC, which possibly resulted in higher effectiveness of EEN in this group of patients.
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Authors | Andrzej Wedrychowicz, Kinga Kowalska-Duplaga, Urszula Jedynak-Wasowicz, Stanislaw Pieczarkowski, Malgorzata Sladek, Przemyslaw Tomasik, Krzysztof Fyderek |
Journal | Journal of pediatric gastroenterology and nutrition
(J Pediatr Gastroenterol Nutr)
Vol. 53
Issue 2
Pg. 150-5
(Aug 2011)
ISSN: 1536-4801 [Electronic] United States |
PMID | 21788755
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dietary Proteins
- TGFB1 protein, human
- Transforming Growth Factor beta1
- Vascular Endothelial Growth Factors
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Topics |
- Adolescent
- Child
- Colitis, Ulcerative
(blood, therapy)
- Crohn Disease
(blood, therapy)
- Dietary Proteins
(administration & dosage)
- Energy Intake
- Enteral Nutrition
- Female
- Humans
- Inflammatory Bowel Diseases
(blood, therapy)
- Male
- Remission Induction
- Severity of Illness Index
- Time Factors
- Transforming Growth Factor beta1
(blood)
- Vascular Endothelial Growth Factors
(blood)
- Weight Gain
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