Serum amyloid-A levels in neonatal necrotizing enterocolitis.
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| Abstract |
We aimed to evaluate serum levels of serum amyloid-A (SAA) both in the diagnosis and monitoring the treatment response of necrotizing enterocolitis (NEC). Forty-five preterm neonates were enrolled in the study, including 15 infants with NEC, 15 with sepsis, and 15 healthy preterm infants. Pre- and posttreatment serum SAA levels were measured. Among patients with NEC, 11 had stage 1 and 4 had stage 2 disease according to the modified Bell's staging criteria. Baseline SAA levels of the infants with NEC were significantly higher than controls (P=0.013) and were significantly lower than those with sepsis (P=0.004). When infants with stage 1 and stage 2 NEC were analyzed separately, baseline SAA levels of the infants with stage 2 NEC were significantly higher than controls (P=0.027) than those with stage 1 NEC (P=0.018), but similar to those with sepsis. There was a trend that baseline SAA levels were also correlated with the Bell stage (r=0.501, P=0.057). Posttreatment SAA levels significantly decreased in infants with sepsis (P=0.002). Pre- and posttreatment SAA levels were similar in patients with stage 1 and 2 NEC. In conclusion, SAA rises in early stages of NEC and may aid in diagnosis as a serum marker.
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| Authors | Zeynep Eras, Suna Oğuz, Evrim Alyamac Dizdar, Fatma Nur Sari, Uğur Dilmen |
| Journal | Journal of clinical laboratory analysis (J Clin Lab Anal) Vol. 25 Issue 4 Pg. 233-7 ( 2011) ISSN: 1098-2825 [Electronic] United States |
| PMID | 21786324 (Publication Type: Journal Article) |
| Copyright | © 2011 Wiley-Liss, Inc. |
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