The dosages of corticosteroid in transforaminal epidural steroid injections for lumbar radicular pain due to a herniated disc.

Abstract

BACKGROUND:

Intervertebral disc herniations are the most common cause of lumbosacral radiculopathy, and transforaminal epidural steroid injection (TFESI) is an important tool in treating lumbosacral radiculopathy. But the ideal dose of corticosteroid in the epidural management of lumbosacral radiculopathy has yet to be determined.

OBJECTIVE:

The aim of this study was to determine the effective dose of steroids in TFESI for pain reduction in patients with lumbosacral radiculopathy.

STUDY DESIGN:

A randomized, double blind, controlled trial.

SETTING:

An interventional pain management practice center.

METHODS:

A total of 160 participants received 2 epidural injections of either 5 mg, 10 mg, 20 mg, or 40 mg of triamcinolone in one week intervals via TFESI. The degree of participant satisfaction and verbal numerical rating scale (VNRS) were assessed at pretreatment, one week, and 2 weeks after the first TFESI.

RESULTS:

The number of participants experiencing pain relief was significantly less than in other groups in the 5 mg triamcinolone group at one week after the first TFESI. There were no significant differences among the groups at one week after the second TFESI. VNRS decreased in the other groups except the triamcinolone 5 mg group at one week after the first TFESI. VNRS decreased in all groups at one week after the second TFESI.

LIMITATIONS:

The limitations include lack of placebo control group and lack of long-term follow-up.

CONCLUSIONS:

We recommend a minimal effective dose of corticosteroid (triamcinolone 10 mg) in TFESI for patients with lumbosacral radiculopathy.

• Authors: Seong-Sik Kang, Byeong-Mun Hwang, Hee-Jeong Son, Il-Young Cheong, Sang-Jin Lee, Sang-Hyun Lee, Tae-Yoon Chung
• Journal: Pain physician (Pain Physician) 2011 Jul-Aug Vol. 14 Issue 4 Pg. 361-70 ISSN: 2150-1149 [Electronic] United States
• PMID: 21785479 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Adrenal Cortex Hormones
• Anti-Inflammatory Agents
• Triamcinolone

Topics

• Adrenal Cortex Hormones (administration & dosage)
• Anti-Inflammatory Agents (administration & dosage)
• Dose-Response Relationship, Drug
• Double-Blind Method
• Female
• Humans
• Injections, Epidural (methods)
• Intervertebral Disc Displacement (complications)
• Lumbar Vertebrae
• Male
• Middle Aged
• Pain (drug therapy, etiology)
• Radiculopathy
• Triamcinolone (administration & dosage)