Abstract | BACKGROUND: STUDY DESIGN: A prospective study of 3,179 patients undergoing interventional techniques with 12,000 encounters and 18,472 procedures from May 2008 to December 2009. STUDY SETTING: An interventional pain management practice, a specialty referral center, a private practice setting in the United States. OBJECTIVE: To assess the rates of adverse events in patients undergoing interventional techniques on antithrombotic therapy with cessation or without cessation and compare them to a group of patients without antithrombotic therapy. METHODS: Measurable outcomes employed were intravascular entry of the needle, bruising, local bleeding, profuse bleeding, local hematoma, oozing, and postoperative soreness.The prospective evaluation was performed utilizing the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement which was developed with recommendations to improve the quality of reporting observational studies. RESULTS: The results of this study illustrated that in one-quarter (3,087) of patient encounters utilizing interventional pain management techniques, antithrombotic therapy was included. Among these, for approximately 55%, or 1,711 encounters, antithrombotic therapy was continued during the interventional techniques, whereas, for 45%, or 1376 encounters, antithrombotic therapy was discontinued. Overall, these results illustrate that while intravascular penetration and oozing were higher in patients with continued antithrombotic therapy, bruising and local bleeding were higher in patients with discontinued antithrombotic therapy without any difference either statistical or clinical in any of the other aspects, either intraoperative, post procedure in the recovery room, or postoperative period. LIMITATIONS: CONCLUSION: No significant prevalence of adverse events was observed in those who continued with or ceased antithrombotic therapy.
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Authors | Laxmaiah Manchikanti, Yogesh Malla, Bradley W Wargo, Kimberly A Cash, Carla D McManus, Kim S Damron, Sheila D Jackson, Vidyasagar Pampati, Bert Fellows |
Journal | Pain physician
(Pain Physician)
2011 Jul-Aug
Vol. 14
Issue 4
Pg. 317-29
ISSN: 2150-1149 [Electronic] United States |
PMID | 21785475
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Cardiovascular Diseases
(prevention & control)
- Chronic Disease
- Female
- Fibrinolytic Agents
(administration & dosage, adverse effects)
- Hemorrhage
(epidemiology)
- Humans
- Male
- Middle Aged
- Neurosurgical Procedures
(adverse effects)
- Orthopedic Procedures
(adverse effects)
- Pain
(surgery)
- Prospective Studies
- Risk Factors
- Thrombolytic Therapy
(adverse effects)
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