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Topical diclofenac gel for the management of periocular actinic keratosis.

AbstractPURPOSE:
We sought to evaluate the efficacy of topical 3% diclofenac gel in the management of periocular actinic keratosis.
METHODS:
Four consecutive patients with periocular actinic keratosis who were treated with topical 3% diclofenac gel twice daily for up to 4 months were included in the study. Patients were reviewed at 1 and 2 months and then as clinically required up to 13 months after treatment.
RESULTS:
All 4 patients had biopsy-proven actinic keratosis. Three of the 4 patients tolerated the therapy well. In 1 patient, an adverse reaction developed, with erythema, crusting, and scaling after 2 months of therapy, which resolved within a month of discontinuing topical diclofenac. In all the patients, a visible decrease in lesion severity was seen after 1 month, and complete resolution, within 4 months. Recurrences occurred in 2 patients at 4 months and 7 months after treatment. These were successfully managed, in one patient, by excision, and in the other, with further 3% diclofenac gel followed by cryotherapy.
CONCLUSION:
The use of 3% diclofenac gel in extraocular sites has been widely described in the dermatology literature. However, no published reports exist of its use in ophthalmology. It may be a useful therapeutic option when used alone in patients with localized disease or to reduce the size of larger, more-diffuse lesions before excision or cryotherapy, leading to improved cosmesis. Furthermore, it may also be useful in patients prone to actinic keratoses, such as organ-transplant recipients, to reduce the need for multiple excision procedures or uncomfortable ablative techniques.
AuthorsRuchika Batra, Sathya Sundararajan, Soupramanien Sandramouli
JournalOphthalmic plastic and reconstructive surgery (Ophthalmic Plast Reconstr Surg) 2012 Jan-Feb Vol. 28 Issue 1 Pg. 1-3 ISSN: 1537-2677 [Electronic] United States
PMID21785377 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Gels
  • Diclofenac
Topics
  • Administration, Topical
  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
  • Diclofenac (administration & dosage)
  • Eyelid Neoplasms (drug therapy)
  • Female
  • Gels
  • Humans
  • Keratosis, Actinic (drug therapy)
  • Male
  • Middle Aged
  • Precancerous Conditions (drug therapy)

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