Serum estradiol does not differentiate stress, mixed and urge incontinent women around menopause. A report from the Women's Health in the Lund Area (WHILA) study.

Abstract

OBJECTIVE:

To outline serum estradiol levels in perimenopausal women with stress, mixed or urge incontinence. We believe the majority of urgency symptoms in perimenopausal women to be caused by a pelvic floor dysfunction and a hypermobility of the bladder neck. If this is the case, there would be no difference in estradiol levels between the groups.

STUDY DESIGN:

SETTING:

University hospital. In the observational Women's Health in the Lund Area study, a subset of 400/2221 women reporting urinary incontinence completed a detailed questionnaire regarding lower urinary tract symptoms and had their serum steroid hormone levels measured. Statistical analyses were made by Chi-square test, nonparametrical tests, ANOVA, multi- and univariate logistic regression analysis.

RESULTS:

Stress incontinence was reported by 196, mixed incontinence by 153 and urge incontinence by 43 women; in 369, serumestradiol values were available. Serum estradiol did not differ significantly between stress incontinent (median 49.5 pmo/l, range 2.63-875.4), urge incontinent (median 31.6 pmol/l, range 2.63-460.7) or mixed incontinent women (median 35.5 pmol/l, range 2.63-787.9, p=0.62). Logistic regression analysis correcting for age, parity, hormonal status, smoking, hysterectomy and BMI also failed to show any difference in estradiol levels between the groups (p=0.41-0.58).

CONCLUSION:

No significant differences in serum estradiol levels between stress, mixed or urge incontinent perimenopausal women could be demonstrated.

• Authors: Maria Andrada Hamer, Karin Källén, Jonas Lidfeldt, Göran Samsioe, Pia Teleman
• Journal: European journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol) Vol. 159 Issue 1 Pg. 209-12 (Nov 2011) ISSN: 1872-7654 [Electronic] Ireland
• PMID: 21782314 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Estradiol

Topics

• Estradiol (blood)
• Female
• Hospitals, University
• Humans
• Logistic Models
• Mass Screening
• Middle Aged
• Perimenopause
• Prevalence
• Severity of Illness Index
• Surveys and Questionnaires
• Sweden (epidemiology)
• Urinary Incontinence (blood, diagnosis, epidemiology)
• Urinary Incontinence, Stress (blood, diagnosis, epidemiology)
• Urinary Incontinence, Urge (blood, diagnosis, epidemiology)
• Women's Health