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[Doppler flow imaging characteristics of blood supply of uterine fibroids on the therapeutic dosage of ultrasound ablation].

AbstractOBJECTIVE:
To explore the relationship between therapeutic dosage of ultrasound ablation in treatment of uterine fibroids and imaging characteristics of bloody supply of uterine fibroids by color Doppler ultrasound imaging.
METHODS:
One hundred and forty-two patients with 168 fibroids were treated by ultrasound ablation. Before treatment, bloody supply of fibroids were classified into grade 0 - 4 by ultrasonography. Three patients lost follow-up with contrast MRI exam within 1 month after treatment, so 165 fibroids were enrolled in this study. Bloody supplies were 9 fibroids in grade 0, 34 fibroids in grade 1, 35 fibroids in grade 2, 55 fibroids in grade 3 and 32 fibroids in grade 4. After 1 month treatment, the treated area without blood supply and ratio of ablation were measured by contrast MRI to evaluate the efficacy of thermal ablation and compare status of blood supple based different therapeutic dosage. According to International Reditherapy for Society (SIR) standard, adverse effect and score of pain were evaluated.
RESULTS:
(1) Ratio of ablation based: ratios of ablation were 79% in grade 0, 89% in grade 1, 92% in grade 2, 86% in grade 3, 71% in grade 4. It reached statistical difference when blood supply of grade 0 compared with those of grade 2 and 3 (P < 0.05) and blood supply of grade 4 compared with those of grade 1, 2, 3 (P < 0.05). (2) Factor of energy efficiency: factor of energy efficiency were 13.19 J/mm(3) in degree 0, 9.54 J/mm(3) in degree 1, 12.91 J/mm(3) in degree 2, 17.83 J/mm(3) in degree 3 and 28.10 J/mm(3) in degree 4. Factor of energy of ablation in degree 4 was significantly higher than those in degree 1, 2 and 3 blood supply (P < 0.05). It exhibit the positive relationship between blood supply and factor of energy of ablation (r = 0.354, P < 0.01). (3) Score of pain and adverse effect: nearly 85% (120/142) patients could tolerate this treatment very well. Those scores of pain were in range of 0 to 4. All patients did not extend their hospitalization and C to F of SIR standard was not recorded.
CONCLUSION:
blood supply of myoma measured by ultrasound could predict dosage of ultrasound ablation, it could help select indicated well patients.
AuthorsJin-yun Chen, Wen-zhi Chen, Li Zhu, Liang-dan Tang, Yong-bin Deng, Ying-jiang Liu, Jian-zhong Zou, Jin Bai, Zhi-biao Wang
JournalZhonghua fu chan ke za zhi (Zhonghua Fu Chan Ke Za Zhi) Vol. 46 Issue 6 Pg. 403-6 (Jun 2011) ISSN: 0529-567X [Print] China
PMID21781577 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Adult
  • Female
  • High-Intensity Focused Ultrasound Ablation (methods)
  • Humans
  • Leiomyoma (blood supply, diagnostic imaging, therapy)
  • Magnetic Resonance Imaging
  • Middle Aged
  • Minimally Invasive Surgical Procedures (methods)
  • Pain Measurement
  • Treatment Outcome
  • Ultrasonography, Doppler, Color (methods)
  • Uterine Neoplasms (blood supply, diagnostic imaging, pathology, therapy)
  • Uterus (blood supply, diagnostic imaging, pathology)
  • Young Adult

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