Abstract |
A 4.5 years old male with myoclonic epilepsy on Valproic acid (VPA) monotherapy, developed an acute pancreatitis. The discontinuation of VPA and substitution with Levetiracetam was followed by clinical improvement but a relapse of the pancreatitis was noted one month later. The investigation excluded a structural abnormality but revealed a heterozygous CTFR mutation. The contribution of the CTFR mutation on this VPA-induced recurrent pancreatitis cannot be ignored.
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Authors | Argirios Dinopoulos, Olga Karapanou, Efi Alexopoulou, Maria Tzetis, Achileas Attilakos, Andreas Fretzayas |
Journal | European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
(Eur J Paediatr Neurol)
Vol. 15
Issue 5
Pg. 453-5
(Sep 2011)
ISSN: 1532-2130 [Electronic] England |
PMID | 21778093
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2011 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Anticonvulsants
- Valproic Acid
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Topics |
- Anticonvulsants
(adverse effects)
- Child, Preschool
- Cystic Fibrosis
(genetics)
- Epilepsies, Myoclonic
(drug therapy, genetics)
- Genetic Carrier Screening
- Humans
- Male
- Pancreatitis
(chemically induced, diagnostic imaging, genetics)
- Ultrasonography
- Valproic Acid
(adverse effects)
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