A nonlinear three-compartment model for the administration of 2',3'-dideoxycytidine by using red blood cells as bioreactors.

Abstract

A non-linear three-compartment model is proposed to describe a new strategy for the administration of 2',3'-dideoxycytidine (ddCyd) in the treatment of HIV infections. The drug is injected after having been encapsulated in a non-diffusible form (ddCMP) into erythrocytes. Numerical solutions show that by this treatment the highest ddCyd blood concentration is strongly reduced and in turn its toxicity, while long-lasting therapeutic effect is assured. The model is compared with experimental data in vitro.

• Authors: F Solimano, G I Bischi, M Bianchi, L Rossi, M Magnani
• Journal: Bulletin of mathematical biology (Bull Math Biol) Vol. 52 Issue 6 Pg. 785-96 ( 1990) ISSN: 0092-8240 [Print] United States
• PMID: 2177675 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Delayed-Action Preparations
• Drug Carriers
• Zalcitabine

Topics

• Delayed-Action Preparations
• Drug Carriers
• Erythrocytes (metabolism)
• HIV Infections (blood, drug therapy)
• Humans
• Models, Biological
• Zalcitabine (administration & dosage, blood)