Abstract |
Treatment with prescription omega-3-acid ethyl esters (POM3) reduces triglycerides (TG) and TG-rich lipoprotein particles, but has been associated with increased fasting glucose (2-6mg/dL). This double-blind, randomized, controlled crossover trial in 19 men and women with hypertriglyceridemia (fasting TG ≥150 and ≤499mg/dL) examined lipid responses and indices of insulin sensitivity and secretion following a liquid meal tolerance test. Six weeks treatment with POM3 vs. corn oil resulted in significant lower mean fasting (-50.1mg/dL, p<0.001) and postprandial TG (-76.1mg/dL, p<0.001), higher mean fasting glucose (2.8mg/dL, p=0.062), reduced mean disposition index (2.1 vs. 2.4, p=0.037), and no change in the median Matsuda composite insulin sensitivity index (3.3 vs. 3.2, p=0.959). These results suggest that POM3 slightly reduces pancreatic β-cell responsiveness to plasma glucose elevation, which may contribute to the rise in fasting glucose sometimes observed with POM3.
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Authors | Kevin C Maki, Andrea L Lawless, Kathleen M Kelley, Mary R Dicklin, Arianne L Schild, Tia M Rains |
Journal | Prostaglandins, leukotrienes, and essential fatty acids
(Prostaglandins Leukot Essent Fatty Acids)
2011 Sep-Oct
Vol. 85
Issue 3-4
Pg. 143-8
ISSN: 1532-2823 [Electronic] Scotland |
PMID | 21775113
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Ltd. All rights reserved. |
Chemical References |
- Blood Glucose
- Lipids
- Prescription Drugs
- Triglycerides
- Docosahexaenoic Acids
- Eicosapentaenoic Acid
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Topics |
- Blood Glucose
- Cross-Over Studies
- Docosahexaenoic Acids
(pharmacology, therapeutic use)
- Double-Blind Method
- Eicosapentaenoic Acid
(pharmacology, therapeutic use)
- Fasting
- Female
- Humans
- Hypertriglyceridemia
(blood, drug therapy)
- Insulin Resistance
- Insulin-Secreting Cells
(drug effects, metabolism)
- Lipids
(blood)
- Male
- Middle Aged
- Postprandial Period
- Prescription Drugs
(pharmacology, therapeutic use)
- Triglycerides
(blood)
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