[Retrospective analysis of antiemetic effect in patients receiving cisplatin].

Abstract

We retrospectively examined the results of antiemetic therapy with granisetron and dexamethasone; with granisetron, dexamethasone and aprepitant; and with palonosetron, dexamethasone and aprepitant, in patients who received chemotherapy with cisplatin at 50 mg/m2 or more for the first time. Vomiting was dramatically reduced by the concomitant administration of aprepitant. There was no difference in this effect when palonosetron was used instead of granisetron as a serotonin receptor antagonist. There was also no significant difference in the percentage of patients without nausea among the 3 groups. The results of this study indicate that vomiting in patients receiving chemotherapy can be controlled using aprepitant in combination with two other drugs.

• Authors: Masahito Yonemura, Takahiro Akita, Shinya Suzuki, Kouichi Gotoh, Makoto Tahara, Atsushi Ohtsu, Yuuichirou Ohe, Kiminori Mouri, Keishirou Izumi
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 38 Issue 7 Pg. 1155-8 (Jul 2011) ISSN: 0385-0684 [Print] Japan
• PMID: 21772101 (Publication Type: Journal Article)

Chemical References

• Antiemetics
• Antineoplastic Agents
• Morpholines
• Aprepitant
• Cisplatin

Topics

• Antiemetics (administration & dosage, therapeutic use)
• Antineoplastic Agents (adverse effects, therapeutic use)
• Aprepitant
• Cisplatin (adverse effects, therapeutic use)
• Female
• Humans
• Male
• Middle Aged
• Morpholines (administration & dosage, therapeutic use)
• Nausea (prevention & control)
• Retrospective Studies
• Vomiting (prevention & control)