Intraocular T-cell lymphoma due to mycosis fungoides and response to intravitreal methotrexate.

Abstract

PURPOSE:

To report a case of mycosis fungoides with subsequent intraocular involvement and good response to intravitreal methotrexate.

DESIGN:

Case report.

METHODS:

Retrospective chart review.

RESULTS:

This is a rare case of intraocular T-cell lymphoma due to mycosis fungoides, which responded to intravitreal methotrexate therapy in a previous vitrectomized eye.

CONCLUSIONS:

Intraocular T-cell lymphoma is a rare manifestation of mycosis fungoides and should be considered in the differential diagnosis of chronic uveitis in patients with this history. Intravitreal methotrexate may be an effective adjunctive treatment for this condition.

• Authors: Rahul Reddy, Stephen Jae Kim
• Journal: Ocular immunology and inflammation (Ocul Immunol Inflamm) Vol. 19 Issue 4 Pg. 234-6 (Aug 2011) ISSN: 1744-5078 [Electronic] England
• PMID: 21770799 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antimetabolites, Antineoplastic
• Methotrexate

Topics

• Antimetabolites, Antineoplastic (administration & dosage)
• Diagnosis, Differential
• Eye Neoplasms (diagnosis, drug therapy, etiology)
• Female
• Humans
• Intravitreal Injections
• Lymphoma, T-Cell (diagnosis, drug therapy, etiology)
• Methotrexate (administration & dosage)
• Middle Aged
• Mycosis Fungoides (complications, drug therapy)
• Rare Diseases
• Skin Neoplasms (complications, drug therapy)