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Sidestream tobacco smoke is a male germ cell mutagen.

Abstract
Active cigarette smoking increases oxidative damage, DNA adducts, DNA strand breaks, chromosomal aberrations, and heritable mutations in sperm. However, little is known regarding the effects of second-hand smoke on the male germ line. We show here that short-term exposure to mainstream tobacco smoke or sidestream tobacco smoke (STS), the main component of second-hand smoke, induces mutations at an expanded simple tandem repeat locus (Ms6-hm) in mouse sperm. We further show that the response to STS is not linear and that, for both mainstream tobacco smoke and STS, doses that induced significant increases in expanded simple tandem repeat mutations in sperm did not increase the frequencies of micronucleated reticulocytes and erythrocytes in the bone marrow and blood of exposed mice. These data show that passive exposure to cigarette smoke can cause tandem repeat mutations in sperm under conditions that may not induce genetic damage in somatic cells. Although the relationship between noncoding tandem repeat instability and mutations in functional regions of the genome is unclear, our data suggest that paternal exposure to second-hand smoke may have reproductive consequences that go beyond the passive smoker.
AuthorsFrancesco Marchetti, Andrea Rowan-Carroll, Andrew Williams, Aris Polyzos, M Lynn Berndt-Weis, Carole L Yauk
JournalProceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 108 Issue 31 Pg. 12811-4 (Aug 02 2011) ISSN: 1091-6490 [Electronic] United States
PMID21768363 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Mutagens
  • Smoke
Topics
  • Animals
  • Dose-Response Relationship, Drug
  • Erythrocytes (drug effects, metabolism)
  • Male
  • Mice
  • Micronuclei, Chromosome-Defective (chemically induced)
  • Micronucleus, Germline (drug effects)
  • Minisatellite Repeats (genetics)
  • Mutagens (toxicity)
  • Mutation (drug effects)
  • Reticulocytes (drug effects, metabolism)
  • Smoke (adverse effects)
  • Spermatozoa (drug effects, metabolism)
  • Tandem Repeat Sequences (genetics)
  • Time Factors
  • Tobacco (chemistry)

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