Abstract |
Sodium stibogluconate, did not bring about significant increase in the production of IL-1, when both specific leishmanial antigen, or non specific Staphylococcus epidermidis was used as stimulus in normal uninfected animals. However, Staph. epidermidis was found to be a better stimulus as it brought about a significant increase (P less than 0.001) in IL-1 production when compared with leishmania antigen. In BALB/c mice infected with L. donovani there was a significant reduction (P less than 0.001) in IL-1 levels on various post infection days irrespective whether Staph. epidermidis or leishmanial antigen was used as stimulus when compared with controls. IL-1 levels were significantly increased (P less than 0.05) when L. donovani infected animals were treated with SSG, after 14 days post infection, irrespective of the stimuli used.
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Authors | S Sodhi, N K Ganguly, N Malla, R C Mahajan |
Journal | The Indian journal of medical research
(Indian J Med Res)
Vol. 91
Pg. 344-8
(Sep 1990)
ISSN: 0971-5916 [Print] India |
PMID | 2176646
(Publication Type: Journal Article)
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Chemical References |
- Interleukin-1
- Antimony Sodium Gluconate
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Topics |
- Animals
- Antimony Sodium Gluconate
(pharmacology)
- Female
- Interleukin-1
(biosynthesis)
- Leishmaniasis, Visceral
(immunology)
- Male
- Mice
- Mice, Inbred BALB C
- Staphylococcus epidermidis
(immunology)
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