Abstract | UNLABELLED: METHODS: One hundred nine subjects in 3 clinical studies at Austin Health were reviewed: 32 controls, 20 subjects with MCI, and 30 patients with AD, 11 with FTLD, 7 with DLB, 5 with PD, and 4 with VaD underwent PET after intravenous injection of 300 MBq of (18)F-florbetaben. Standardized uptake value ratios (SUVR) using the cerebellar cortex as a reference region were calculated between 90 and 110 min after injection. RESULTS: When compared with the other groups, AD patients demonstrated significantly higher SUVRs (P < 0.0001) in neocortical areas. Most AD patients (96%) and 60% of MCI subjects showed diffuse cortical (18)F-florbetaben retention. In contrast, only 9% of FTLD, 25% of VaD, 29% of DLB, and no PD patients and 16% of controls showed cortical binding. Although there was a correlation between Mini Mental State Examination and β- amyloid burden in the MCI group, no correlation was observed in controls, FTLD or AD. CONCLUSION: (18)F-florbetaben had high sensitivity for AD, clearly distinguished patients with FTLD from AD, and provided results comparable to those reported with (11)C-Pittsburgh Compound B in a variety of neurodegenerative diseases.
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Authors | Victor L Villemagne, Kevin Ong, Rachel S Mulligan, Gerhard Holl, Svetlana Pejoska, Gareth Jones, Graeme O'Keefe, Uwe Ackerman, Henri Tochon-Danguy, J Gordon Chan, Cornelia B Reininger, Lueder Fels, Barbara Putz, Beate Rohde, Colin L Masters, Christopher C Rowe |
Journal | Journal of nuclear medicine : official publication, Society of Nuclear Medicine
(J Nucl Med)
Vol. 52
Issue 8
Pg. 1210-7
(Aug 2011)
ISSN: 1535-5667 [Electronic] United States |
PMID | 21764791
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amyloid beta-Peptides
- Aniline Compounds
- Fluorine Radioisotopes
- Radioisotopes
- Stilbenes
- 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene
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Topics |
- Aged
- Aged, 80 and over
- Alzheimer Disease
(diagnostic imaging)
- Amyloid beta-Peptides
(metabolism)
- Aniline Compounds
(pharmacology)
- Case-Control Studies
- Cerebellum
(diagnostic imaging)
- Dementia
(diagnostic imaging)
- Female
- Fluorine Radioisotopes
(pharmacology)
- Frontotemporal Dementia
(diagnostic imaging)
- Humans
- Image Processing, Computer-Assisted
- Lewy Bodies
(diagnostic imaging)
- Male
- Middle Aged
- Neurodegenerative Diseases
(diagnostic imaging)
- Positron-Emission Tomography
(methods)
- Radioisotopes
(pharmacology)
- Stilbenes
(pharmacology)
- Treatment Outcome
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