Abstract | BACKGROUND:
Hepatitis delta is caused by infection with the hepatitis D virus (HDV) and is considered the most severe form of viral hepatitis. Treatment options for hepatitis delta are limited, with only 25% of patients responding to interferon (IFN)-alfa-based therapies. The role of the adaptive immune system in controlling HDV infection during spontaneous or treatment-induced viral clearance is not well understood. METHODS: We studied HDV-specific cytokine production of peripheral blood mononuclear cells stimulated with HDV peptide pools as well as serum cytokine levels in well-characterized patients with chronic HDV infection before and during pegylated- interferon-alfa±adefovir therapy. RESULTS: Hepatitis D virus-specific interleukin (IL)-2, IFN-γ-, interferon-inducible protein-10 and IL-10-responses were detectable in 53%, 35%, 65% and 6% of hepatitis delta patients. HDV-specific IFN-γ responses tended to be more common in patients with low HDV viral loads. HDV-specific cytokine responses declined during pegylated (PEG)-IFNa therapy and patterns of changes were associated with the treatment response. Serum cytokine levels also showed distinct changes during PEG-IFNa treatment. CONCLUSION:
|
Authors | Jan Grabowski, Cihan Yurdaydìn, Kalliopi Zachou, Peter Buggisch, Wolf P Hofmann, Jerzy Jaroszewicz, Verena Schlaphoff, Michael P Manns, Markus Cornberg, Heiner Wedemeyer, HIDIT-1 study group |
Journal | Liver international : official journal of the International Association for the Study of the Liver
(Liver Int)
Vol. 31
Issue 9
Pg. 1395-405
(Oct 2011)
ISSN: 1478-3231 [Electronic] United States |
PMID | 21762356
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Copyright | © 2011 John Wiley & Sons A/S. |
Chemical References |
- Antiviral Agents
- Cytokines
- Interferon-alpha
- Organophosphonates
- RNA, Viral
- Recombinant Proteins
- Polyethylene Glycols
- adefovir
- Adenine
- peginterferon alfa-2a
|
Topics |
- Adenine
(analogs & derivatives, therapeutic use)
- Adult
- Analysis of Variance
- Antiviral Agents
(therapeutic use)
- Cells, Cultured
- Chi-Square Distribution
- Cytokines
(blood)
- Drug Therapy, Combination
- Europe
- Female
- Hepatitis D, Chronic
(diagnosis, drug therapy, immunology)
- Hepatitis Delta Virus
(genetics, immunology)
- Humans
- Interferon-alpha
(therapeutic use)
- Leukocytes, Mononuclear
(immunology, virology)
- Male
- Middle Aged
- Organophosphonates
(therapeutic use)
- Polyethylene Glycols
(therapeutic use)
- RNA, Viral
(blood)
- Recombinant Proteins
(therapeutic use)
- Time Factors
- Treatment Outcome
- Viral Load
- Young Adult
|