Abstract | OBJECTIVE: METHOD: Stealth liposomes with different phospholipids composition, such as soybean phosphatidycholine (SPC), hydrogenated soybean phosphatidylcholine (HSPC) and the complex of SPC and HSPC, were prepared by ammonium sulfate transmembrane gradient method. Pharmaceutical properties such as shape, encapsulation efficiency and size of three stealth liposomes were compared intensively. Anti- tumor activity of SPC, HSPC and novel stealth liposomes composed of both SPC and HSPC were compared by established mouse liver cancer H22 model. Meanwhile, the mice body weight and immune organ weight were also compared. RESULT: The encapsulation efficiency of novel, SPC and HSPC stealth liposomes were 77.7%, 64.8% and 74.8%, respectively. The mean diameters of them were less than 100 nm. The tumor inhibition rate of novel, HSPC and SPC stealth liposomes were 57.88%, 49.15%, 23.37%, respectively. The mice body weight, thymus gland index of three stealth liposomes group and spleen index of novel stealth liposomes group had no significant difference with the negative group while SPC and HSPC stealth liposomes group increased the spleen index. CONCLUSION:
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Authors | Minglei Chen, Jun Chen, Ting Hou, Yun Fang, Weiwei Sun, Rongrong Hu, Baocang Cai |
Journal | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
(Zhongguo Zhong Yao Za Zhi)
Vol. 36
Issue 7
Pg. 864-7
(Apr 2011)
ISSN: 1001-5302 [Print] China |
PMID | 21761723
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Liposomes
- Phospholipids
- brucine
- Strychnine
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Topics |
- Animals
- Antineoplastic Agents
(chemistry, pharmacology)
- Body Weight
(drug effects)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Humans
- Liposomes
(adverse effects, chemistry)
- Mice
- Particle Size
- Phospholipids
(chemistry)
- Strychnine
(analogs & derivatives, chemistry)
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