Abstract | OBJECTIVE: METHODS: Patients were included if they had MAPT or GRN mutations, positive family history with pathologically proven FTLD in the patient or first-degree relative, or were part of FTD-MND families. All patients and 10 age- and gender-matched controls underwent measurement of brain perfusion using (99m)Tc-HMPAO SPECT. We used SPM8 to perform image processing and voxel-based group analyses (p < 0.001). Gender and age were included as nuisance variables in the design matrices. RESULTS: Of the 29 patients with familial FTLD, 19 had familial FTLD-TDP (GRN mutations in 6), and 10 had MAPT mutations. At clinical presentation, familial FTLD-TDP patients were older at onset (p = 0.030) and had more memory deficits (p = 0.011), whereas patients with MAPT had more naming deficits (p < 0.001) and obsessive-compulsive behavior (p = 0.001). The between-groups SPECT analyses revealed significantly less perfusion in the right frontal lobe, precuneus, cuneus, and inferior parietal lobule in familial FTLD-TDP, whereas significantly less perfusion was found in the left temporal and inferior frontal gyri in MAPT. Post hoc analysis of familial FTLD-TDP with unknown genetic defect vs MAPT revealed less perfusion in the right frontal and parietal lobe. CONCLUSION: Familial FTLD-TDP shows relatively more posterior hypoperfusion, including the precuneus and inferior parietal lobule, possibly related to significant memory impairment. Patients with MAPT were characterized by impaired perfusion of the temporal regions and naming deficits.
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Authors | H Seelaar, J M Papma, G Garraux, I de Koning, A E Reijs, R Valkema, A J M Rozemuller, E Salmon, J C van Swieten |
Journal | Neurology
(Neurology)
Vol. 77
Issue 4
Pg. 384-92
(Jul 26 2011)
ISSN: 1526-632X [Electronic] United States |
PMID | 21753175
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- DNA-Binding Proteins
- GRN protein, human
- Intercellular Signaling Peptides and Proteins
- MAPT protein, human
- Progranulins
- tau Proteins
- Technetium Tc 99m Exametazime
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Topics |
- Brain
(blood supply, diagnostic imaging)
- DNA-Binding Proteins
(genetics, physiology)
- Female
- Frontotemporal Lobar Degeneration
(complications, genetics, physiopathology, psychology)
- Humans
- Intercellular Signaling Peptides and Proteins
(genetics, physiology)
- Male
- Memory Disorders
(complications, diagnostic imaging, genetics, physiopathology)
- Middle Aged
- Mutation
- Neuropsychological Tests
(statistics & numerical data)
- Obsessive-Compulsive Disorder
(complications, diagnostic imaging, genetics, physiopathology)
- Progranulins
- Technetium Tc 99m Exametazime
- Tomography, Emission-Computed, Single-Photon
(methods)
- tau Proteins
(genetics, physiology)
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