The efficacy of Ankaferd Blood Stopper in heparin-induced hemostatic abnormality in a rat epistaxis model.

Abstract

OBJECTIVE:

To assess the in vivo hemostatic effect of Ankaferd Blood Stopper (ABS).

STUDY DESIGN:

An experimental study of an animal anterior epistaxis model.

SETTING:

A tertiary care university hospital.

SUBJECTS AND METHODS:

Wistar rats were randomized into 4 groups of 7 each: group 1, control, no pretreatment, irrigated with saline; group 2, no pretreatment, irrigated with ABS; group 3, control, heparin pretreatment, irrigated with saline; and group 4, heparin pretreatment, irrigated with ABS. In all groups, a standardized rat epistaxis model was obtained by cutting the anterior nasal septal mucosa. To control bleeding, compressive dressings were placed after instilling 1 mL of either ABS or saline to the bleeding area. The hemostasis time and amount of nasal bleeding were measured in all groups to compare the treatments without and with ABS.

RESULTS:

Without heparin pretreatment, ABS shortened the hemostasis time by 1.57 minutes (P = .003) and reduced the amount of the bleeding by 0.35 g (P = .006). With heparin pretreatment, ABS shortened the hemostasis time by 2.86 minutes and reduced the amount of the bleeding by 0.49 g (both P = .002).

CONCLUSION:

ABS irrigation was more effective than saline irrigation for treating anterior epistaxis hemostasis in animals using a compressive dressing with or without heparin pretreatment.

• Authors: Ismail Iynen, Ozgur Sogut, Rustu Kose
• Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (Otolaryngol Head Neck Surg) Vol. 145 Issue 5 Pg. 840-4 (Nov 2011) ISSN: 1097-6817 [Electronic] England
• PMID: 21750339 (Publication Type: Journal Article)

Chemical References

• Hemostatics
• Plant Extracts
• ankaferd blood stopper
• Heparin

Topics

• Animals
• Compression Bandages
• Epistaxis (therapy)
• Hemostatics (administration & dosage, therapeutic use)
• Heparin (administration & dosage)
• Male
• Plant Extracts (administration & dosage, therapeutic use)
• Random Allocation
• Rats
• Rats, Wistar
• Therapeutic Irrigation
• Time Factors