Study on the expression and clinical significances of lewis y antigen and integrin αv, β3 in epithelial ovarian tumors.

Abstract

OBJECTIVE:

To detect the expression and clinical significances of Lewis y antigen and integrin αv, β3 in epithelial ovarian tumors, and to explore the expression correlation between Lewis y antigen and integrin αv, β3.

METHODS:

Immunohistochemical staining was performed in 95 cases of epithelial ovarian cancer, 37 cases of borderline tumors, 20 cases of benign tumors, and 20 cases of normal ovarian tissue, for the detection of Lewis y antigen and integrin αv, β3 expressions, and to analyze the relationship between Lewis y antigen and integrin, and the relationship between clinical and pathological parameters of ovarian cancer. In addition, immunofluorescence double labeling was utilized to detect the expression correlation between Lewis y antigen and integrin αv, β3 in ovarian cancer.

RESULTS:

In epithelial ovarian tumors, the expression rate of Lewis y antigen was 81.05%, significantly higher than that of borderline (51.53%) (P < 0.05) and benign (25%) (P < 0.01) tumors, and normal ovarian tissues (0) (P < 0.01). The expression rate of integrin αv, β3 in malignant epithelial ovarian tumors was 78.95% and 82.11%, respectively, significantly higher than that of the borderline (45.94%, 40.54%) (both P < 0.05), benign group (10.00%, 15.00%) (both P < 0.01) and normal ovary group (5%, 15%) (both P < 0.01).

CONCLUSIONS:

Lewis y and integrins αv, β3 are relevant to pelvic and abdominal diffusion and metastasis of ovarian cancer cells, suggesting that these two molecules mediate a boosting function for tumor metastasis.

• Authors: Yifei Wang, Juanjuan Liu, Bei Lin, Changzhi Wang, Quanrong Li, Shuice Liu, Limei Yan, Shulan Zhang, Masao Iwamori
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 12 Issue 6 Pg. 3409-21 ( 2011) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 21747684 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fluorescent Dyes
• Integrin alphaVbeta3
• Lewis Blood Group Antigens
• Lewis Y antigen

Topics

• Abdominal Neoplasms (metabolism, pathology, secondary)
• Adult
• Aged
• Carcinoma, Ovarian Epithelial
• Female
• Fluorescent Dyes (chemistry)
• Humans
• Immunohistochemistry
• Integrin alphaVbeta3 (metabolism)
• Lewis Blood Group Antigens (metabolism)
• Middle Aged
• Neoplasm Staging
• Neoplasms, Glandular and Epithelial (metabolism, pathology)
• Ovarian Neoplasms (metabolism, pathology)