[Synchronization dynamics in the neuronal work of the neocortex and hippocampus during learning before and after the administration of nootropics and narcotics].
|
| Abstract |
The basal difference in action of the studied drugs was that nootropics (phenybut in a dose of 40 mg/kg and pyracetam in a dose of 200-400 mg/kg) did not change the initial action of pain reinforcement on synchronism in responses of the cortical neurones of alert nonimmobilized rabbits by inhibitory type (coincidence of the presence and absence of impulse activity) towards its decrease, while narcotics of various types (ethanol in a dose of 4-6 mg/kg, morphine-like opiate DAGO and opioid peptide DADLE in doses of 250 mkg/kg) eliminated the action of pain reinforcement on synchronism in responses of the cortical neurones both by inhibitory and activation (time of coincidence only of the presence of impulse activity) types. These and other drugs mainly weakened the initial action of both the inhibitory and reinforced light flashes of synchronism in neurones activity both by inhibitory and activation types. There was no constant parallelism between changes of synchronization and the frequency of the cortical impulses.
|
|---|---|
| Authors | G I Shul'gina, N V Okhotnikov |
| Journal | Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova (Zh Vyssh Nerv Deiat Im I P Pavlova) 1990 Jul-Aug Vol. 40 Issue 4 Pg. 732-8 ISSN: 0044-4677 [Print] Russia (Federation) |
| Vernacular Title | Dinamika sinkhroniizatsii v rabote neĭronov novoĭ kory i gippokampa pri obuchenii do i posle vvedeniia nootropov i nerkotikov. |
| PMID | 2174615 (Publication Type: Comparative Study, English Abstract, Journal Article) |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!