[Capillary beta-hydroxybutyrate determination for monitoring diabetic ketoacidosis].

Abstract

BACKGROUND AND OBJECTIVE:

Diabetic ketoacidosis (DKA) is the most severe acute metabolic complication of type 1 diabetes mellitus. Insulin treatment is commonly guided by plasma glucose levels and changes in venous blood gases, while β-hydroxibutyrate (BHB) levels are rarely measured. The study objective was to evaluate the value of capillary BHB monitoring in the course and resolution of DKA.

PATIENTS AND METHODS:

Thirty patients with type 1 diabetes admitted for DKA were enrolled. A standard protocol including monitoring of blood glucose, venous blood gases, semiquantitative ketonuria, and capillary BHB was used. Patients were divided into three groups by time to DKA resolution (group 1:<24 h, group 2: 24-48 h, group 3: >48 h), and BHB results were compared to all other biochemical measurements.

RESULTS:

Mean laboratory results upon admission were: blood glucose 415 (standard deviation [SD] 106) mg/dL; bicarbonate 9.6 (SD 1.5) mmol/L; pH 7.13 (SD 0.04); BHB 4.33 (SD 0.48) mmol/L, and ketonuria 3+ in 22 patients and 4+ in 6. BHB correlated well with bicarbonate (r=-0.24139; P=0.0161) and pH (r=-0.56419; P<0.0001). BHB normalized earlier than ketonuria in all cases (group 1: 15.5 vs 18.8 hours P<0.05; group 2: 18.2 vs 23.5 hours P<0.01; group 3: 37.3 vs 41.7 hours P<0.01). Ten percent of patients still had ketonuria when blood ketone levels were already normal (<0.5 mmol/L).

CONCLUSION:

BHB measurement is an easy, practical, and reliable monitoring method in DKA and may be used as a parameter to adjust insulin treatment.

• Authors: Beatriz Rodríguez-Merchán, Ana Casteràs, Eva Domingo, Francisco José Nóvoa, Yaiza López, José Manuel Cabezas-Agricola, Teresa Rivero, Mónica Parramón, Jordi Mesa
• Journal: Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion (Endocrinol Nutr) 2011 Aug-Sep Vol. 58 Issue 7 Pg. 347-52 ISSN: 1579-2021 [Electronic] Spain
• Vernacular Title: Betahidroxibutirato capilar en la monitorización de la cetoacidosis diabética.
• PMID: 21737365 (Publication Type: English Abstract, Journal Article)
• Copyright: Copyright © 2011 SEEN. Published by Elsevier Espana. All rights reserved.

Chemical References

• 3-Hydroxybutyric Acid

Topics

• 3-Hydroxybutyric Acid (blood)
• Adult
• Capillaries
• Diabetic Ketoacidosis (blood)
• Female
• Humans
• Male