The role of opioid antagonist efficacy and constitutive opioid receptor activity in the opioid withdrawal syndrome in mice.

Abstract

On the basis of efficacy, opioid antagonists are classified as inverse opioid agonists (e.g. naltrexone) or neutral opioid antagonists (e.g. 6β-naltrexol). This study examined the interaction between naltrexone and 6β-naltrexol in the precipitated opioid withdrawal syndrome in morphine dependent mice. Furthermore, the possible contribution of constitutive opioid receptor activity to precipitated withdrawal was evaluated using increasing levels of morphine dependence. In the first experiment, low doses of 6β-naltrexol antagonized naltrexone precipitated withdrawal while high doses acted additively. All doses of naltrexone increased 6β-naltrexol's potency to precipitate withdrawal. The next experiment examined changes in antagonist potency to precipitate withdrawal with increasing morphine dependence. Mice were exposed to morphine for 1-6 days and then withdrawal was precipitated. Naltrexone was more potent than 6β-naltrexol at all the time points. The ED(50) of both drugs decreased at the same rate suggesting that increased dependence produced no change in constitutive opioid receptor activity. Taken together these results indicate that the functional efficacy of 6β-naltrexol is dose-dependent and that constitutive opioid receptor activity did not change as opioid dependence increased from 1 to 6 days.

• Authors: Dipesh M Navani, Sunil Sirohi, Priyanka A Madia, Byron C Yoburn
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 99 Issue 4 Pg. 671-5 (Oct 2011) ISSN: 1873-5177 [Electronic] United States
• PMID: 21736895 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2011 Elsevier B.V. All rights reserved.

Chemical References

• Narcotic Antagonists
• Narcotics
• Receptors, Opioid
• 6 beta-hydroxynaltrexone
• Naltrexone

Topics

• Animals
• Behavior, Animal (drug effects)
• Dose-Response Relationship, Drug
• Male
• Mice
• Morphine Dependence (psychology)
• Naltrexone (analogs & derivatives, pharmacology)
• Narcotic Antagonists (pharmacology)
• Narcotics
• Receptors, Opioid (agonists, drug effects, physiology)
• Substance Withdrawal Syndrome (drug therapy, psychology)